Document Detail

Peripheral and central chemoreceptor control of ventilation during exercise in humans.
MedLine Citation:
PMID:  8000356     Owner:  NLM     Status:  MEDLINE    
The stability of arterial blood gas tensions and pH during steady-state moderate exercise has suggested an important humoral element of ventilatory control in humans. However, the involvement of central and peripheral chemoreflexes in this humoral control remains controversial. This reflects, in large part, technical and interpretational limitations inherent in currently used estimators of chemoreflex "sensitivity." Evidence suggests that the central chemoreceptors (a) contribute little during moderate exercise, given the relative stability of cerebrospinal pH, (b) constrain the hyperpnea of high-intensity exercise, consequent to the respiratory compensation for the metabolic acidemia, and (c) may play a role in the respiratory compensation during chronic metabolic acidemia. In contrast, the peripheral chemoreceptors appear to (a) exert considerable influence on ventilatory kinetics in moderate exercise, but are less important in the steady state, and (b) induce much of the respiratory compensation of high-intensity exercise.
S A Ward
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Canadian journal of applied physiology = Revue canadienne de physiologie appliquée     Volume:  19     ISSN:  1066-7814     ISO Abbreviation:  Can J Appl Physiol     Publication Date:  1994 Sep 
Date Detail:
Created Date:  1995-01-24     Completed Date:  1995-01-24     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9306274     Medline TA:  Can J Appl Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-33     Citation Subset:  IM; S    
Department of Physiology, St. George's Hospital Medical School, London, England.
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MeSH Terms
Acidosis / physiopathology
Carotid Body / physiology
Chemoreceptor Cells* / physiology
Exercise / physiology*
Physical Conditioning, Animal / physiology
Respiration / physiology*

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