Document Detail


Peripheral or central administration of nitric oxide synthase inhibitor affects feeding behavior in chicks.
MedLine Citation:
PMID:  17618151     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We investigated the effect of peripheral or central administration of N(G)-nitro-L-arginine methyl ester (L-NAME), a nitric oxide (NO) synthase inhibitor, on food intake in layer and broiler chicks (Gallus gallus). The intraperitoneal administration of L-NAME significantly decreased food intake in both broiler and layer chicks while the administration of D-NAME, an inactive form of L-NAME, had no effect. The intracerebroventricular (ICV) injection of L-NAME did not affect food intake in broiler chicks. However, ICV injection of L-NAME increased food intake in layer chicks while the injection of D-NAME had no effect. In addition to this, L-NAME-induced feeding was negated with the co-injection of L-arginine, suggesting that NO acts as a feeding-inhibitor signal in the brain of layer chicks. The present study revealed that administration of NO synthase inhibitor affected food intake in chicks, but the effect might be changed by chick strain and position of the injection.
Authors:
Md Sakirul Islam Khan; Tetsuya Tachibana; Yuko Hasebe; Naoto Masuda; Hiroshi Ueda
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-06-19
Journal Detail:
Title:  Comparative biochemistry and physiology. Part A, Molecular & integrative physiology     Volume:  148     ISSN:  1095-6433     ISO Abbreviation:  Comp. Biochem. Physiol., Part A Mol. Integr. Physiol.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-13     Completed Date:  2007-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9806096     Medline TA:  Comp Biochem Physiol A Mol Integr Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  458-62     Citation Subset:  IM    
Affiliation:
Department of Agrobiological Science, Faculty of Agriculture, Ehime University, Matsuyama 790-8566, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Animals, Newborn
Arginine / administration & dosage
Chickens / metabolism,  physiology*
Enzyme Inhibitors / administration & dosage*
Feeding Behavior / drug effects*
Injections, Intraperitoneal
Injections, Intraventricular
Male
NG-Nitroarginine Methyl Ester / administration & dosage*
Nitric Oxide / metabolism
Nitric Oxide Synthase / antagonists & inhibitors*,  metabolism
Species Specificity
Chemical
Reg. No./Substance:
0/Enzyme Inhibitors; 10102-43-9/Nitric Oxide; 50903-99-6/NG-Nitroarginine Methyl Ester; 74-79-3/Arginine; EC 1.14.13.39/Nitric Oxide Synthase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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