Document Detail


Peripheral blood stem cell collection in pediatric patients: feasibility of leukapheresis under anesthesia in uncompliant small children with solid tumors.
MedLine Citation:
PMID:  16035098     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Leukapheresis demands patient's compliance and adequate vascular accesses, which can require invasive methods in very small children whose treatment protocol includes hemopoietic stem cell collection for myeloablative chemotherapy and stem cell rescue. Since 1998, at the Istituto Nazionale Tumori of Milan, in selected uncompliant small children, the placement of peripheral vascular accesses and leukapheresis have been performed at the same time under general anesthesia. Peripheral venous cannulas were positioned for blood collection, while blood was returned through either peripheral cannulas or mono-lumen central catheters previously installed for chemotherapy. A continuous-flow cell separator was used for leukapheresis. Between 1998 and 2003, 47 children with solid tumors underwent anesthesia for a total of 54 leukaphereses. The patients' age ranged from 12.7 to 93 months (median 30.3) and their weight ranged from 7 to 20 kg (median 14.1). Neither metabolic nor anesthesiological complications were recorded. In 89% of cases, the CD 34(+) cell target was achieved at a single harvest; the median number of CD 34(+) cells was 10.8 x 10(6)/kg/leukapheresis (range 1-117) and the median collection efficiency was 63.4% (range 25-100.6). Leukapheresis under anesthesia is feasible and safe in very low-weight children whose compliance is lacking due to age and disease.
Authors:
Fernando Ravagnani; Paola Coluccia; Paola Notti; Flavio Arienti; Alvaro Bompadre; Mario Avella; Fabio Bozzi; Elena Barzanò; Marta Podda; Sandro Pupa; Roberto Luksch
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical apheresis     Volume:  21     ISSN:  0733-2459     ISO Abbreviation:  J Clin Apher     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-08-21     Completed Date:  2006-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8216305     Medline TA:  J Clin Apher     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-91     Citation Subset:  IM    
Affiliation:
Immunohematology and Transfusion Medicine Service, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milan, Italy.
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General* / adverse effects,  methods
Antigens, CD34
Catheters, Indwelling
Child
Child, Preschool
Feasibility Studies
Humans
Infant
Leukapheresis / methods*,  standards
Leukocyte Count
Neoplasms / therapy*
Peripheral Blood Stem Cell Transplantation / methods
Treatment Refusal*
Chemical
Reg. No./Substance:
0/Antigens, CD34

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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