| Peripheral blood stem cell apheresis in normal donors: feasibility and yield of second collections. | |
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MedLine Citation:
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PMID: 9029035 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We report 13 normal peripheral blood stem cell (PBSC) donors who had a second PBSC collection for allogeneic transplantation performed after the first. The median interval between the first and second collection was 5 months. Mobilization was achieved with filgrastim (12 microg/kg/d). No significant difference was found in the median pre-apheresis leucocyte count (x10(9)/l) between the two donations (40.2 v 38.5; P = 0.91). The median apheresis yield (x10(6) CD34+ cells/litre blood processed, first apheresis) was also similar (28 v 27.3; P = 0.91). Filgrastim-related adverse events were comparable. These data suggest that second PBSC collections are feasible, similarly tolerated and provide comparable apheresis yields. |
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Authors:
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P Anderlini; J Lauppe; D Przepiorka; D Seong; R Champlin; M Körbling |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of haematology Volume: 96 ISSN: 0007-1048 ISO Abbreviation: Br. J. Haematol. Publication Date: 1997 Feb |
Date Detail:
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Created Date: 1997-03-06 Completed Date: 1997-03-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0372544 Medline TA: Br J Haematol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 415-7 Citation Subset: IM |
Affiliation:
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Department of Hematology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Blood Component Removal Blood Donors Female Filgrastim / therapeutic use Hematopoietic Stem Cell Transplantation / methods* Humans Leukocyte Count Male Middle Aged Retrospective Studies |
| Chemical | |
Reg. No./Substance:
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121181-53-1/Filgrastim |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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