Document Detail


Peripheral blood leukocyte gene expression patterns and metabolic parameters in habitually snoring and non-snoring children with normal polysomnographic findings.
MedLine Citation:
PMID:  21286499     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Children who snore but do not have gas exchange abnormalities or alterations of sleep architecture have primary snoring (PS). Since increasing evidence suggest that PS may be associated with morbidity, we hypothesized that assessing genome-wide gene expression in peripheral blood leukocytes (PBL) will identify a distinct signature in PS children.
METHODS: Children (aged 4-9 years) with and without habitual snoring and a normal PSG were designated as either PS or controls. Whole genome expression profiles of PBL and metabolic parameters in 30 children with PS and 30 age-, gender-, ethnicity-, and BMI-matched controls were compared. Pathway-focused gene network analysis of the PBL transcriptome was performed. Metabolic parameters were measured in an independent follow-up cohort of 98 children (64 PS and 34 controls) to evaluate the computationally derived findings.
RESULTS: PS was not associated with a distinct transcriptional signature in PBL. Exploratory functional network analysis of enriched gene sets identified a number of putative pathways-including those mapping to insulin signaling, adipocyte differentiation, and obesity-with significant alterations in glucose metabolism and insulin sensitivity emerging in the follow-up cohort of children with PS, but no differences in lipid profiles.
CONCLUSIONS: PS children do not exhibit global perturbations in their PBL transcriptional response, suggesting that current normative PSG criteria are overall valid. However, subtle differences in functionally coherent pathways involved in glycemic homeostasis were detected and confirmed in a larger independent pediatric cohort indicating that PS may carry increased risk for end-organ morbidity in susceptible children.
Authors:
Abdelnaby Khalyfa; Sina A Gharib; Jinkwan Kim; Oscar Sans Capdevila; Leila Kheirandish-Gozal; Rakesh Bhattacharjee; Mohamed Hegazi; David Gozal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-02-01
Journal Detail:
Title:  Sleep     Volume:  34     ISSN:  1550-9109     ISO Abbreviation:  Sleep     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-02     Completed Date:  2011-06-22     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  7809084     Medline TA:  Sleep     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-60     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, University of Chicago, 5721 S. Maryland Avenue, Chicago, IL 60637, USA.
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Biological Markers
Blood Glucose
Child
Child, Preschool
Cohort Studies
Female
Follow-Up Studies
Gene Expression*
Gene Expression Profiling / methods
Genome-Wide Association Study / methods
Humans
Insulin / blood
Leukocytes*
Lipids / blood
Male
Microarray Analysis
Polysomnography / methods*
Snoring / blood*
Grant Support
ID/Acronym/Agency:
HL065270/HL/NHLBI NIH HHS; HL074223/HL/NHLBI NIH HHS; HL086662/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Blood Glucose; 0/Insulin; 0/Lipids
Comments/Corrections
Comment In:
Sleep. 2011 Feb;34(2):133-4   [PMID:  21286229 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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