Document Detail


Peripheral blood and intestinal lymphocyte sub-populations in Crohn's disease.
MedLine Citation:
PMID:  1081463     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Immunofluorescent technques were utilized to study the nature and distribution of cells forming the inflammatory infiltrate in Crohn's disease. Tissue from resected ileum (one patient) or colon (one patient) when compared with corresponding control tissues contained increased numbers of B and T lymphocytes. B-cells of IgG class predominated in the mucosal lamina propria, whereas T-cells were prominent in the deeper layers of inflamed bowel. Inflammatory cells bearing Fc receptors were also present in these tissues. Decreased peripheral blood T-cell numbers returned to normal after resection of the involved bowel in the two patients studied. Impaired cellular immunity in Crohn's disease may thus result from T-cell sequestration in or loss from involved segments of intestine.
Authors:
R G Strickland; G Husby; W C Black; R C Williams
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gut     Volume:  16     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-27     Completed Date:  1976-02-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  847-53     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
B-Lymphocytes / immunology*
Colon / immunology,  pathology
Crohn Disease / immunology*,  pathology
Female
Humans
Ileum / immunology,  pathology
Immunoglobulin A / analysis
Immunoglobulin E / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Intestinal Mucosa / immunology,  pathology
Male
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 37341-29-0/Immunoglobulin E
Comments/Corrections

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