Document Detail

Peripheral blood and intestinal lymphocyte sub-populations in Crohn's disease.
MedLine Citation:
PMID:  1081463     Owner:  NLM     Status:  MEDLINE    
Immunofluorescent technques were utilized to study the nature and distribution of cells forming the inflammatory infiltrate in Crohn's disease. Tissue from resected ileum (one patient) or colon (one patient) when compared with corresponding control tissues contained increased numbers of B and T lymphocytes. B-cells of IgG class predominated in the mucosal lamina propria, whereas T-cells were prominent in the deeper layers of inflamed bowel. Inflammatory cells bearing Fc receptors were also present in these tissues. Decreased peripheral blood T-cell numbers returned to normal after resection of the involved bowel in the two patients studied. Impaired cellular immunity in Crohn's disease may thus result from T-cell sequestration in or loss from involved segments of intestine.
R G Strickland; G Husby; W C Black; R C Williams
Related Documents :
19676123 - Doublecortin and cam kinase-like-1 and leucine-rich-repeat-containing g-protein-coupled...
7380203 - Isolation and characterization of colonic intraepithelial and lamina proprial lymphocytes.
10706883 - Stat5 activation contributes to growth and viability in bcr/abl-transformed cells.
Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Gut     Volume:  16     ISSN:  0017-5749     ISO Abbreviation:  Gut     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-27     Completed Date:  1976-02-27     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2985108R     Medline TA:  Gut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  847-53     Citation Subset:  AIM; IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
B-Lymphocytes / immunology*
Colon / immunology,  pathology
Crohn Disease / immunology*,  pathology
Ileum / immunology,  pathology
Immunoglobulin A / analysis
Immunoglobulin E / analysis
Immunoglobulin G / analysis
Immunoglobulin M / analysis
Intestinal Mucosa / immunology,  pathology
T-Lymphocytes / immunology*
Reg. No./Substance:
0/Immunoglobulin A; 0/Immunoglobulin G; 0/Immunoglobulin M; 37341-29-0/Immunoglobulin E

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Hemodynamic evaluation of patients with intrahepatic portal hypertension. Relationship between bleed...
Next Document:  A prospective comparative trial between early endoscopy and radiology in acute upper gastrointestina...