| Peripheral blood galectin-1-expressing T and natural killer cells in normal pregnancy and preeclampsia. | |
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MedLine Citation:
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PMID: 21292557 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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The purpose of this study was to determine whether the proportion of galectin-1-expressing peripheral blood T and NK cells is altered in normal pregnancy and preeclampsia (PE). We also examined whether circulating levels of galectin-1 and anti-galectin-1 autoantibodies are affected in PE. Seventy preeclamptic patients, 75 healthy pregnant and 21 healthy non-pregnant women were involved in this study. Serum galectin-1 and anti-galectin-1 autoantibody levels were measured by ELISA. Intracellular galectin-1 expression of lymphocytes was determined with flow cytometry. Serum galectin-1 and anti-galectin-1 IgG levels did not differ significantly between the healthy pregnant and the PE group. In healthy pregnant women, significantly higher percentage of T and NK cells expressed gal-1 in their cytoplasma than in healthy non-pregnant women. However, the proportion of galectin-1-expressing peripheral blood T and NK cells was markedly decreased in PE compared to normal pregnancy, which might contribute to the activation of innate and acquired immune cells. |
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Authors:
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Attila Molvarec; Sandra M Blois; Balázs Stenczer; Gergely Toldi; Irene Tirado-Gonzalez; Mika Ito; Tomoko Shima; Satoshi Yoneda; Barna Vásárhelyi; János Rigó; Shigeru Saito |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-1 |
Journal Detail:
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Title: Clinical immunology (Orlando, Fla.) Volume: - ISSN: 1521-7035 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-2-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883537 Medline TA: Clin Immunol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2010 Elsevier Inc. All rights reserved. |
Affiliation:
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First Department of Obstetrics and Gynecology, Semmelweis University, Budapest, Hungary. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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