Document Detail


Peripheral blood dendritic cell subsets from patients with monoclonal gammopathies show an abnormal distribution and are functionally impaired.
MedLine Citation:
PMID:  18245015     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Objectives. The information currently available about dendritic cells (DCs) in patients with different types of monoclonal gammopathy (MG) is limited and frequently controversial. In the present study, we analyzed the ex vivo distribution as well as the phenotypic and functional characteristics of peripheral blood (PB) DCs from different types of MG. Methods. For this purpose, 61 untreated patients in total with MG were analyzed-MG of undetermined significance (MGUS), 29 cases; multiple myeloma (MM), 28 cases; and plasma cell leukemia (PCL), 4 cases-in comparison with a group of 10 healthy controls. Results. Our results show an absolute overall higher number of all subsets of PB DCs in PCL, together with lower numbers of myeloid DCs in MM patients. From a phenotypic point of view, PB DC subsets from all types of MG expressed significantly higher levels of HLA molecules and altered patterns of expression of the CD2, CD11c, CD16, CD22, CD62L, and CD86 molecules, in association with altered patterns of secretion of inflammatory cytokines. Conclusion. In summary, we show the existence of significant abnormalities in the distribution, phenotype, and pattern of secretion of inflammatory cytokines by different subsets of PB DCs from patients with MGs, which could reflect a potentially altered homing of DCs, together with a greater in vivo activation and lower responsiveness of PB DCs, which are already detectable in MGUS patients.
Authors:
Marta Martín-Ayuso; Julia Almeida; Martín Pérez-Andrés; Rebeca Cuello; Josefina Galende; Maria Isabel González-Fraile; Guillermo Martín-Nuñez; Fernando Ortega; Maria Jesús Rodríguez; Jesús F San Miguel; Alberto Orfao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The oncologist     Volume:  13     ISSN:  1083-7159     ISO Abbreviation:  Oncologist     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-02-04     Completed Date:  2008-04-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9607837     Medline TA:  Oncologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  82-92     Citation Subset:  IM    
Affiliation:
Servicio de Citometría & Departamento de Medicina, University of Salamanca, Salamanca, Spain.
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Case-Control Studies
Dendritic Cells / pathology
Female
Humans
Leukemia, Plasma Cell / blood,  physiopathology
Male
Middle Aged
Multiple Myeloma / blood,  physiopathology
Paraproteinemias / blood,  pathology*,  physiopathology*
Phenotype

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