Document Detail


Peripheral blood T-cell subpopulations in the very low birth weight (less than 1,500-g) infant.
MedLine Citation:
PMID:  3492138     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of monoclonal antibodies to cell-surface antigens has provided method for characterizing distinct subpopulations of T-cells. In the present study we have quantified peripheral blood T-cell subpopulations in premature infants born weighing less than 1,500 g (1123 +/- 223 g) and ranging in gestational age from 25 to 32 weeks. The relative proportion of T4 cells in the very low birth weight (VLBW) infants was markedly higher at 1 week and 1 month of age (mean +/- SEM; 67.5 +/- 4.1 and 59.2 +/- 1.6) than in adult controls (47.2 +/- 1.5). The percentage of T4 cells remained elevated until 6 months of age, when it decreased to a level comparable to that in adults. In contrast, the proportion of T8 cells was significantly lower than the adult level at 1 week and 1 month of age. The T4/T8 ratio in the VLBW infants was higher at 1 week (4.3 +/- 0.5) and 1 month (3.5 +/- 0.2) than in adult controls (2.0 +/- 0.1). Thereafter, the T4/T8 ratio decreased but was still significantly higher than that in adult controls at 6 months of age (2.6 +/- 0.2). The absolute numbers of total T-cells (T3) and T8 and T4 cells were significantly higher in VLBW infants. The numbers of T8 cells were significantly lower in the first month of life than at 3-6 months of age. These alterations in the T-cell subsets in the first 6 months of life suggest that postnatal T-cell phenotypic changes in VLBW infants may parallel the T-cell ontogenetic process which occurs during the last trimester of pregnancy in full-term infants.
Authors:
M Ballow; K L Cates; J C Rowe; C Goetz; A G Pantschenko
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  American journal of hematology     Volume:  24     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1987 Jan 
Date Detail:
Created Date:  1987-01-30     Completed Date:  1987-01-30     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  85-92     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Blood Cells / classification*
Cell Survival
Esterases / metabolism
Humans
Infant, Low Birth Weight*
Infant, Newborn
Leukocyte Count
Lymphocytes / cytology
Monocytes / enzymology
T-Lymphocytes / classification*,  cytology
Grant Support
ID/Acronym/Agency:
HD-16481/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
EC 3.1.-/Esterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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