| Peripheral augmentation index and vascular inflammation in autosomal dominant polycystic kidney disease. | |
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MedLine Citation:
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PMID: 21292815 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Cardiovascular disease is the leading cause of premature mortality in autosomal dominant polycystic kidney disease (ADPKD). We examined peripheral augmentation index (AIx) as a measure of systemic vascular function and circulating markers of vascular inflammation in patients with ADPKD. METHODS: Fifty-two ADPKD patients with hypertension and estimated glomerular filtration rate (eGFR) <60 mL/min/1.73 m(2), 50 ADPKD patients with hypertension and eGFR ≥ 60 mL/min/1.73 m(2), 42 normotensive ADPKD patients with eGFR ≥ 60 mL/min/1.73 m(2) and 51 normotensive healthy controls were enrolled in this study. AIx was measured from peripheral artery tone recordings using finger plethysmography. Serum levels of soluble intercellular adhesion molecule (ICAM)-1, vascular cell adhesion molecule-1, P-selectin, E-selectin, soluble Fas (sFas) and Fas ligand (FasL) were measured as markers of vascular inflammation. RESULTS: AIx was higher in all three patient groups with ADPKD compared to healthy controls (P < 0.05). AIx was similar between the normotensive ADPKD patients with eGFR ≥ 60 mL/min/1.73 m(2) and hypertensive ADPKD patients with eGFR < 60 mL/min/1.73 m(2) (P > 0.05). ICAM, P-selectin, E-selectin and sFas were higher and FasL lower in all ADPKD groups compared to controls (P < 0.05). ICAM, P-selectin and E-selectin were similar between the normotensive ADPKD patients with eGFR ≥ 60 mL/min/1.73 m(2) and hypertensive ADPKD patients with eGFR < 60 mL/min/1.73 m(2) (P > 0.05). According to multiple regression analysis, predictors of AIx in ADPKD included age, height, heart rate and mean arterial pressure (P < 0.05). Vascular inflammatory markers were not predictors of AIx in ADPKD. CONCLUSIONS: Systemic vascular dysfunction, manifesting as an increase in AIx and vascular inflammation is evident in young normotensive ADPKD patients with preserved renal function. Vascular inflammation is not associated with elevated AIx in ADPKD. |
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Authors:
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Kevin S Heffernan; Jeffrey T Kuvin; Mark J Sarnak; Ronald D Perrone; Dana C Miskulin; Darya Rudym; Priya Chandra; Richard H Karas; Vandana Menon |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-02-03 |
Journal Detail:
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Title: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association Volume: 26 ISSN: 1460-2385 ISO Abbreviation: Nephrol. Dial. Transplant. Publication Date: 2011 Aug |
Date Detail:
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Created Date: 2011-08-01 Completed Date: 2011-12-20 Revised Date: 2013-05-26 |
Medline Journal Info:
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Nlm Unique ID: 8706402 Medline TA: Nephrol Dial Transplant Country: England |
Other Details:
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Languages: eng Pagination: 2515-21 Citation Subset: IM |
Affiliation:
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Department of Epidemiology and Public Health, National University of Singapore. kheffernan@tuftsmedicalcetner.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Blood Pressure Case-Control Studies E-Selectin / metabolism Female Glomerular Filtration Rate Heart Rate Humans Hypertension / diagnosis, etiology*, metabolism Inflammation / diagnosis, etiology*, metabolism Intercellular Adhesion Molecule-1 / metabolism Kidney Function Tests Male Middle Aged P-Selectin / metabolism Polycystic Kidney, Autosomal Dominant / complications*, metabolism Prognosis Vascular Cell Adhesion Molecule-1 / metabolism Vascular Diseases / diagnosis, etiology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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K23 DK67303/DK/NIDDK NIH HHS; K24 DK078204/DK/NIDDK NIH HHS; RR000054/RR/NCRR NIH HHS; T32 HL069770-06/HL/NHLBI NIH HHS; UL1 RR025752/RR/NCRR NIH HHS; UO1DK62411/DK/NIDDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/E-Selectin; 0/P-Selectin; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1 |
| Comments/Corrections | |
Comment In:
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Nephrol Dial Transplant. 2011 Oct;26(10):3417
[PMID:
21795246
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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