Document Detail


Peripheral adrenoceptors: the impetus behind glucose dysregulation and insulin resistance.
MedLine Citation:
PMID:  23140239     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
It is now accepted that several pharmacological drug treatments trigger clinical manifestations of glucose dysregulation such as hyperglycemia, glucose intolerance and insulin resistance, in part through poorly understood mechanisms. Persistent sympathoadrenal activation is linked to glucose dysregulation and insulin resistance, both of which significantly increase the risk of emergent endocrinological disorders including metabolic syndrome and Type 2 diabetes mellitus. Through use of targeted mutagenesis and pharmacological methods, preclinical and clinical research has confirmed physiological glucoregulatory roles for several peripheral α- and β-adrenoceptor subtypes. Adrenoceptor isoforms in the pancreas (α(2A) and β(2) ), skeletal muscle (α(1A) and β(2) ), liver (α(1A & B) and β(2) ) and adipose tissue (α(1A) and β(1 & 3) ) are convincing etiological targets accountable for both immediate and long-lasting alterations in blood glucose homeostasis. As significant overlap exists between the therapeutic applications of numerous classes of drugs and their associated adverse side-effects, a better understanding of peripheral adrenoceptor-mediated glucose metabolism is thus warranted. Therefore, while providing a brief review of glucose homeostasis in the periphery, the present review addresses both functional and pathophysiological roles of the mammalian α(1) , α(2) , and β-adrenoceptor isoforms in whole-body glucose turnover. We highlight evidence on the clinical use of common adrenergic drugs and their impacts on glucose metabolism © 2012 British Society for Neuroendocrinology.
Authors:
H N Boyda; R M Procyshyn; C C Y Pang; A M Barr
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-11-12
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  -     ISSN:  1365-2826     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 British Society for Neuroendocrinology.
Affiliation:
Department of Anesthesiology, Pharmacology & Therapeutics, University of British, Columbia.
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