Document Detail


Peripheral vascular endothelial function in patients with hypertrophic cardiomyopathy.
MedLine Citation:
PMID:  20102901     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Patients with hypertrophic cardiomyopathy (HC) have coronary microvascular dysfunction, which is an independent predictor of adverse left ventricular remodeling, systolic dysfunction, and mortality in these patients. Whether these defects in vasomotor function are localized to the coronary arteries or whether systemic vasomotor dysfunction is present in patients with HC has not yet been adequately examined. The aim of this study was to test the hypothesis that patients with HC have altered peripheral vascular endothelial function. Subjects without coronary artery disease (CAD) and those with CAD served as negative and positive controls, respectively. Conduit artery endothelium-dependent vasomotion was assessed with ultrasound by measuring flow-mediated dilation of the brachial artery. Flow-mediated dilation was lower in patients with HC compared with those without CAD (p <0.05) but was similar in patients with CAD (p = NS). In conclusion, vasomotor dysfunction in HC is not restricted to the coronary vasculature. Patients with HC have impaired peripheral conduit vessel endothelial function, and the magnitude of impairment is similar to that seen in older patients with advanced CAD.
Authors:
Kevin S Heffernan; Craig A Napolitano; Martin S Maron; Eshan A Patvardhan; Ayan R Patel; Natesa G Pandian; Richard H Karas; Jeffrey T Kuvin
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  The American journal of cardiology     Volume:  105     ISSN:  1879-1913     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-27     Completed Date:  2010-03-04     Revised Date:  2014-09-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  112-5     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Brachial Artery / physiopathology*,  ultrasonography
Cardiomyopathy, Hypertrophic / physiopathology*
Endothelium, Vascular / physiopathology*,  ultrasonography
Female
Follow-Up Studies
Humans
Male
Middle Aged
Prognosis
Prospective Studies
Ultrasonography, Doppler
Vasodilation / physiology*
Grant Support
ID/Acronym/Agency:
T32 HL069770/HL/NHLBI NIH HHS; T32 HL069770-06A1/HL/NHLBI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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