Document Detail

Peripheral T-cell lymphoma with involvement of the expanded mantle zone.
MedLine Citation:
PMID:  16633785     Owner:  NLM     Status:  MEDLINE    
Peripheral T-cell lymphoma (PTCL) with a nodular architecture is rare. Recently, two variants have been described with infiltration of the B-cell follicle, one variant that localizes to the marginal zone with a so-called perifollicular growth pattern, and a variant that localizes to the germinal center. These lymphomas have a CD4+ phenotype and may express Bcl-6. We have studied five similar cases of PTCL with involvement of the B-cell follicle. However, our cases differ from the cases previously described by their predominant and frequently patchy involvement of the expanded mantle zone of the B-cell follicle at onset. Later biopsies in three of the cases show diffuse infiltration of the lymph node, without features of angioimmunoblastic TCL (AILT). All cases expressed Bcl-6 in addition to CD4. Cytogenetics was available in four of the cases but revealed no recurrent chromosomal aberrations or changes associated with other types of PTCL. No mutations of the BCL-6 gene were observed. Together, the cases seem to have an intermediately aggressive clinical behavior. Whether our cases are part of a spectrum of PTCLs that encompasses previously described variants with predominant marginal zone or germinal center infiltration or they represent a separate T-cell lymphoma type remains to be demonstrated by a study of more of such cases.
Ida Münster Ikonomou; Anne Tierens; Gunhild Troen; Hege Vangstein Aamot; Sverre Heim; Grete F Lauritzsen; Helen Vålerhaugen; Jan Delabie
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Publication Detail:
Type:  Case Reports; Journal Article     Date:  2006-04-22
Journal Detail:
Title:  Virchows Archiv : an international journal of pathology     Volume:  449     ISSN:  0945-6317     ISO Abbreviation:  Virchows Arch.     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-06-28     Completed Date:  2006-11-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9423843     Medline TA:  Virchows Arch     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  78-87     Citation Subset:  IM    
Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway.
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MeSH Terms
Antigens, CD4 / metabolism
Combined Modality Therapy
DNA-Binding Proteins / metabolism
Fatal Outcome
Germinal Center / pathology
Lymph Nodes / pathology*
Lymphoma, Mantle-Cell / metabolism,  pathology*,  therapy
Lymphoma, T-Cell, Peripheral / metabolism,  pathology*,  therapy
Middle Aged
Remission Induction
Tumor Markers, Biological / metabolism
Reg. No./Substance:
0/Antigens, CD4; 0/BCL6 protein, human; 0/DNA-Binding Proteins; 0/Tumor Markers, Biological

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