| Peripheral T-cell lymphoma with involvement of the expanded mantle zone. | |
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MedLine Citation:
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PMID: 16633785 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Peripheral T-cell lymphoma (PTCL) with a nodular architecture is rare. Recently, two variants have been described with infiltration of the B-cell follicle, one variant that localizes to the marginal zone with a so-called perifollicular growth pattern, and a variant that localizes to the germinal center. These lymphomas have a CD4+ phenotype and may express Bcl-6. We have studied five similar cases of PTCL with involvement of the B-cell follicle. However, our cases differ from the cases previously described by their predominant and frequently patchy involvement of the expanded mantle zone of the B-cell follicle at onset. Later biopsies in three of the cases show diffuse infiltration of the lymph node, without features of angioimmunoblastic TCL (AILT). All cases expressed Bcl-6 in addition to CD4. Cytogenetics was available in four of the cases but revealed no recurrent chromosomal aberrations or changes associated with other types of PTCL. No mutations of the BCL-6 gene were observed. Together, the cases seem to have an intermediately aggressive clinical behavior. Whether our cases are part of a spectrum of PTCLs that encompasses previously described variants with predominant marginal zone or germinal center infiltration or they represent a separate T-cell lymphoma type remains to be demonstrated by a study of more of such cases. |
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Authors:
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Ida Münster Ikonomou; Anne Tierens; Gunhild Troen; Hege Vangstein Aamot; Sverre Heim; Grete F Lauritzsen; Helen Vålerhaugen; Jan Delabie |
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Publication Detail:
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Type: Case Reports; Journal Article Date: 2006-04-22 |
Journal Detail:
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Title: Virchows Archiv : an international journal of pathology Volume: 449 ISSN: 0945-6317 ISO Abbreviation: Virchows Arch. Publication Date: 2006 Jul |
Date Detail:
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Created Date: 2006-06-28 Completed Date: 2006-11-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9423843 Medline TA: Virchows Arch Country: Germany |
Other Details:
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Languages: eng Pagination: 78-87 Citation Subset: IM |
Affiliation:
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Department of Pathology, The Norwegian Radium Hospital, University of Oslo, Oslo, Norway. ida.m.munster.ikonomou@radiumhospitalet.no |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antigens, CD4 / metabolism Combined Modality Therapy DNA-Binding Proteins / metabolism Fatal Outcome Female Germinal Center / pathology Humans Lymph Nodes / pathology* Lymphoma, Mantle-Cell / metabolism, pathology*, therapy Lymphoma, T-Cell, Peripheral / metabolism, pathology*, therapy Male Middle Aged Remission Induction Tumor Markers, Biological / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antigens, CD4; 0/BCL6 protein, human; 0/DNA-Binding Proteins; 0/Tumor Markers, Biological |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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