Document Detail

Peripheral serotonin enhances lipid metabolism by accelerating bile acid turnover.
MedLine Citation:
PMID:  20685881     Owner:  NLM     Status:  MEDLINE    
Serotonin is synthesized by two distinct tryptophan hydroxylases, one in the brain and one in the periphery. The latter is known to be unable to cross the blood-brain barrier. These two serotonin systems have apparently independent functions, although the functions of peripheral serotonin have yet to be fully elucidated. In this study, we have investigated the physiological effect of peripheral serotonin on the concentrations of metabolites in the circulation and in the liver. After fasting, mice were ip injected with 1 mg serotonin. The plasma glucose concentration was significantly elevated between 60 and 270 min after the injection. In contrast, plasma triglyceride, cholesterol, and nonesterified fatty acid concentrations were decreased. The hepatic glycogen synthesis and concentrations were significantly higher at 240 min. At the same time, the hepatic triglyceride content was significantly lower than the basal levels noted before the serotonin injection, whereas the hepatic cholesterol content was significantly higher by 60 min after the injection. Furthermore, serotonin stimulated the contraction of the gallbladder and the excretion of bile. After the serotonin injection, there was a significant induction of apical sodium-dependent bile acid transporter expression, resulting in a decrease in the concentration of bile acids in the feces. Additionally, data are presented to show that the functions of serotonin are mediated through diverse serotonin receptor subtypes. These data indicate that peripheral serotonin accelerates the metabolism of lipid by increasing the concentration of bile acids in circulation.
Hitoshi Watanabe; Daisuke Akasaka; Hideki Ogasawara; Kan Sato; Masato Miyake; Kazuki Saito; Yu Takahashi; Takashi Kanaya; Ikuro Takakura; Tetsuya Hondo; Guozheng Chao; Michael T Rose; Shyuichi Ohwada; Kouichi Watanabe; Takahiro Yamaguchi; Hisashi Aso
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-08-04
Journal Detail:
Title:  Endocrinology     Volume:  151     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-22     Completed Date:  2010-11-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4776-86     Citation Subset:  AIM; IM    
Cellular Biology Laboratory, Graduate School of Agricultural Science, Tohoku University, 1-1 Tsutsumidori-Amamiyamachi, Aoba-ku, Sendai 981-8555, Japan.
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MeSH Terms
Bile Acids and Salts / blood,  metabolism*
Dose-Response Relationship, Drug
Fasting / blood,  metabolism
Gallbladder / drug effects,  metabolism,  physiology
Glucose / metabolism
Glycogen / metabolism
Ileum / drug effects,  metabolism
Injections, Intraperitoneal
Insulin / blood,  metabolism
Lipid Metabolism / drug effects*,  physiology
Liver / drug effects,  metabolism
Mice, Inbred C57BL
Serotonin / administration & dosage,  blood,  metabolism,  pharmacology*
Reg. No./Substance:
0/Bile Acids and Salts; 11061-68-0/Insulin; 50-67-9/Serotonin; 50-99-7/Glucose; 9005-79-2/Glycogen

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