Document Detail


Peripheral δ-opioid receptors attenuate the exercise pressor reflex.
MedLine Citation:
PMID:  23934854     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In rats with ligated femoral arteries, the exercise pressor reflex is exaggerated, an effect that is attenuated by stimulation of peripheral μ-opioid receptors on group IV metabosensitive afferents. In contrast, δ-opioid receptors are expressed mostly on group III mechanosensitive afferents, a finding that prompted us to determine whether stimulation of these opioid receptors could also attenuate the exaggerated exercise pressor reflex in "ligated" rats. We found femoral arterial injection of [D-Pen2,D-Pen5]enkephalin (DPDPE; 1.0 μg), a δ-opioid agonist, significantly attenuated the pressor and cardioaccelerator components of the exercise pressor reflex evoked by hindlimb muscle contraction in both rats with ligated and patent femoral arteries. DPDPE significantly decreased the pressor responses to muscle mechanoreflex activation, evoked by tendon stretch, in ligated rats only. DPDPE (1.0 μg) had no effect in either group on the pressor and cardioaccelerator responses to capsaicin (0.2 μg), which primarily stimulates group IV afferents. DPDPE (1.0 μg) had no effect on the pressor and cardioaccelerator responses to lactic acid (24 mM), which stimulates group III and IV afferents, in rats with patent femoral arteries but significantly decreased the pressor response in ligated rats. Western blots revealed the amount of protein comprising the δ-opioid receptor was greater in dorsal root ganglia innervating hindlimbs with ligated femoral arteries than in dorsal root ganglia innervating hindlimbs with patent femoral arteries. Our findings support the hypothesis that stimulation of δ-opioid receptors on group III afferents attenuated the exercise pressor reflex.
Authors:
Anna K Leal; Katsuya Yamauchi; Joyce Kim; Victor Ruiz-Velasco; Marc P Kaufman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2013-08-09
Journal Detail:
Title:  American journal of physiology. Heart and circulatory physiology     Volume:  305     ISSN:  1522-1539     ISO Abbreviation:  Am. J. Physiol. Heart Circ. Physiol.     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-10-16     Completed Date:  2013-12-06     Revised Date:  2014-10-15    
Medline Journal Info:
Nlm Unique ID:  100901228     Medline TA:  Am J Physiol Heart Circ Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  H1246-55     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Analgesics, Opioid / pharmacology
Animals
Blood Pressure / drug effects,  physiology
Enkephalin, D-Penicillamine (2,5)- / pharmacology
Femoral Artery / surgery
Heart Rate / drug effects,  physiology
Hemodynamics / drug effects,  physiology
Ligation
Male
Mechanoreceptors / drug effects,  physiology*
Muscle, Skeletal / drug effects,  innervation*,  physiology
Physical Conditioning, Animal / physiology*
Rats
Rats, Sprague-Dawley
Receptors, Opioid, delta / agonists,  physiology*
Reflex / drug effects,  physiology*
Grant Support
ID/Acronym/Agency:
F32 HL-108406/HL/NHLBI NIH HHS; P01 HL-096570/HL/NHLBI NIH HHS; P01 HL096570/HL/NHLBI NIH HHS; R01 AR-059397/AR/NIAMS NIH HHS; R01 AR059397/AR/NIAMS NIH HHS
Chemical
Reg. No./Substance:
0/Analgesics, Opioid; 0/Receptors, Opioid, delta; 88373-73-3/Enkephalin, D-Penicillamine (2,5)-
Comments/Corrections

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