| Peripheral and Central Inputs Shape Network Dynamics in the Developing Visual Cortex In Vivo. | |
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MedLine Citation:
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PMID: 22264606 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Spontaneous network activity constitutes a central theme during the development of neuronal circuitry [1, 2]. Before the onset of vision, retinal neurons generate waves of spontaneous activity that are relayed along the ascending visual pathway [3, 4] and shape activity patterns in these regions [5, 6]. The spatiotemporal nature of retinal waves is required to establish precise functional maps in higher visual areas, and their disruption results in enlarged axonal projection areas (e.g., [7-10]). However, how retinal inputs shape network dynamics in the visual cortex on the cellular level is unknown. Using in vivo two-photon calcium imaging, we identified two independently occurring patterns of network activity in the mouse primary visual cortex (V1) before and at the onset of vision. Acute manipulations of spontaneous retinal activity revealed that one type of network activity largely originated in the retina and was characterized by low synchronicity (L-) events. In addition, we identified a type of high synchronicity (H-) events that required gap junction signaling but were independent of retinal input. Moreover, the patterns differed in wave progression and developmental profile. Our data suggest that different activity patterns have complementary functions during the formation of synaptic circuits in the developing visual cortex. |
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Authors:
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Friederike Siegel; J Alexander Heimel; Judith Peters; Christian Lohmann |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-18 |
Journal Detail:
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Title: Current biology : CB Volume: - ISSN: 1879-0445 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-23 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9107782 Medline TA: Curr Biol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Synapse and Network Development, Netherlands Institute for Neuroscience, 1105 BA Amsterdam, The Netherlands; Department of Cellular and Systems Neurobiology, Max Planck Institute of Neurobiology, 82152 Martinsried, Germany. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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