Document Detail


Peripheral and central GLP-1 receptor populations mediate the anorectic effects of peripherally administered GLP-1 receptor agonists, liraglutide and exendin-4.
MedLine Citation:
PMID:  21693680     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONCLUSION: Food intake suppression after peripheral administration of exendin-4 and liraglutide is mediated by activation of GLP-1R expressed on vagal afferents as well as direct CNS GLP-1R activation.
Authors:
Scott E Kanoski; Samantha M Fortin; Myrtha Arnold; Harvey J Grill; Matthew R Hayes
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-06-21
Journal Detail:
Title:  Endocrinology     Volume:  152     ISSN:  1945-7170     ISO Abbreviation:  Endocrinology     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-07-25     Completed Date:  2011-09-21     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3103-12     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Depressants / pharmacology*
Body Weight / drug effects
Brain / physiology*
Calcitonin / pharmacology
Eating / drug effects
Glucagon-Like Peptide 1 / analogs & derivatives*,  pharmacology
Male
Peptide Fragments / pharmacology
Peptides / pharmacology*
Rats
Rats, Sprague-Dawley
Receptors, Glucagon / agonists,  physiology*
Vagus Nerve / physiology
Venoms / pharmacology*
Grant Support
ID/Acronym/Agency:
DK085435/DK/NIDDK NIH HHS; DK089752/DK/NIDDK NIH HHS; DK21397/DK/NIDDK NIH HHS
Chemical
Reg. No./Substance:
0/Appetite Depressants; 0/Peptide Fragments; 0/Peptides; 0/Receptors, Glucagon; 0/Venoms; 0/glucagon-like peptide-1 receptor; 133514-43-9/exendin (9-39); 47931-85-1/salmon calcitonin; 839I73S42A/liraglutide; 89750-14-1/Glucagon-Like Peptide 1; 9007-12-9/Calcitonin; 9P1872D4OL/exenatide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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