| Peripheral blood cytokine profiling during pregnancy and post-partum periods. | |
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MedLine Citation:
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PMID: 20712812 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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PROBLEM: Pregnancy requires that the maternal immune system adapt to prevent rejection of the fetal semi-allograft. This immunologic adaptation may contribute to pregnancy-related alterations in disease susceptibility and severity of infections from viral pathogens such as influenza virus. METHOD OF STUDY: As part of a larger study investigating the maternal systemic immune response during pregnancy, peripheral blood was collected three times during pregnancy and twice post-partum to measure serum levels of 23 cytokines, chemokines, and growth factors. This longitudinal study design allowed each woman's post-partum blood draw to serve as her own comparison, thus controlling for interpersonal variability in expression levels. RESULTS: When compared to the post-partum samples, significant pregnancy-related changes in IFNγ, TNFα, VEGF, GCSF, Eotaxin, and MCP-1 expression were observed. These changes have significant immunologic effects in vivo and in culture. CONCLUSION: Pregnancy-associated changes to steady state serum cytokines may have important immunologic consequence. |
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Authors:
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Thomas A Kraus; Rhoda S Sperling; Stephanie M Engel; Yungtai Lo; Lisa Kellerman; Tricia Singh; Martine Loubeau; Yongchao Ge; Jose L Garrido; Marta Rodríguez-García; Thomas M Moran |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural Date: 2010-08-16 |
Journal Detail:
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Title: American journal of reproductive immunology (New York, N.Y. : 1989) Volume: 64 ISSN: 1600-0897 ISO Abbreviation: Am. J. Reprod. Immunol. Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-05 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8912860 Medline TA: Am J Reprod Immunol Country: Denmark |
Other Details:
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Languages: eng Pagination: 411-26 Citation Subset: IM |
Copyright Information:
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© 2010 John Wiley & Sons A/S. |
Affiliation:
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Department of Obstetrics, Gynecology and Reproductive Sciences, Mount Sinai School of Medicine, New York, NY 10029, USA. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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N01-AI-50028/AI/NIAID NIH HHS; U19A1062623//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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