| Peripheral arterial occlusive disease: evaluation of a high spatial and temporal resolution 3-T MR protocol with a low total dose of gadolinium versus conventional angiography. | |
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MedLine Citation:
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PMID: 20959539 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate a peripheral magnetic resonance (MR) angiographic protocol combining continuous table movement (CTM) MR angiography of the entire runoff vasculature with time-resolved (TWIST) 3-T MR angiography of the calves with a total gadolinium dose of 0.1 mmol per kilogram of body weight. MATERIALS AND METHODS: In this retrospective institutional review board-approved study, 31 consecutive patients (22 men, nine women; mean age, 65 years ± 14 [standard deviation]) with peripheral arterial occlusive disease who had undergone a low-dose MR angiographic protocol that consisted of CTM MR angiography (repetition time msec/echo time msec, 2.4/1.0; 21° flip angle; voxel size, 1.2 mm(3); gadolinium dose, 0.07 mmol per kilogram of body weight) and TWIST MR angiography (2.8/1.1; 20° flip angle; voxel size, 1.1 mm(3); temporal resolution, 4.8-5.5 sec, gadolinium dose, 0.03 mmol/kg), as well as digital subtraction angiography (DSA), were included. Two radiologists rated image quality and stenosis degree on four-point scales. The accuracy of stenosis gradation and, specifically, the detection of high-grade stenoses (stenosis of 70%-99%) with CTM MR angiography alone and with the combined protocol were compared with accuracy of stenosis gradation and detection of high-grade stenoses with DSA. Means and standard deviations were calculated for all data. Interobserver agreement was determined with κ statistics. Positive and negative predictive values, sensitivity, specificity, and overall diagnostic accuracy were calculated for CTM MR angiography alone and for the combined protocol. RESULTS: For CTM MR angiography, image quality was good or excellent in 95.9% of vessel segments; for TWIST MR angiography, image quality was good or excellent in 94.3% and 97.8% of vessel segments for readers 1 and 2, respectively. The combined protocol resulted in high overall diagnostic accuracy of more than 80% for detection of stenosis and diagnostic accuracy of 93.5% for detection of high-grade vessel stenosis. Inclusion of TWIST MR angiography increased diagnostic value over that achieved with CTM MR angiography alone. CONCLUSION: A combined MR angiographic approach in which a low total gadolinium dose (0.1 mmol/kg) is used yields excellent image quality and is accurate in the diagnosis of peripheral arterial stenosis. |
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Authors:
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Ulrike I Attenberger; Stefan Haneder; John N Morelli; Steffen J Diehl; Stefan O Schoenberg; Henrik J Michaely |
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Publication Detail:
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Type: Evaluation Studies; Journal Article Date: 2010-10-19 |
Journal Detail:
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Title: Radiology Volume: 257 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-11-18 Completed Date: 2011-01-10 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 879-87 Citation Subset: AIM; IM |
Copyright Information:
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© RSNA, 2010. |
Affiliation:
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Institute of Clinical Radiology and Nuclear Medicine, University Medical Center Mannheim, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167 Mannheim, Germany. ulrike.attenberger@medma.uni-heidelberg.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Angiography, Digital Subtraction Arterial Occlusive Diseases / diagnosis* Contrast Media / administration & dosage Female Humans Magnetic Resonance Angiography / methods* Male Meglumine / administration & dosage Middle Aged Organometallic Compounds / administration & dosage Peripheral Vascular Diseases / diagnosis* Retrospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Contrast Media; 0/Organometallic Compounds; 0/gadoterate meglumine; 138071-82-6/gadobutrol; 6284-40-8/Meglumine |
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