| Peripartum interneuronal coupling in the supraoptic nucleus. | |
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MedLine Citation:
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PMID: 11911868 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the supraoptic nucleus (SON), the incidence of conducting gap junctions (gjs), as indicated by dye coupling, is low in cycling females, but dramatically elevated in nursing mothers. Functionally, this is consistent with the well-established presence of synchronous milk ejection bursts among oxytocin neurons only in the lactating rat. In situ hybridization data, however, revealed elevated gj mRNA expression on the last day of pregnancy, a time when burst firing by putative oxytocin neurons is absent. Using Lucifer Yellow dye coupling, we determined the incidence of high conductance gjs in SONs of proestrous, immediately prepartum, postpartum non-lactating, lactating day 1, and lactating day 9-10 rats. Results indicate that coupling incidence is high only at times when milk ejection bursts are known to occur, and that the elevated gj mRNA expression seen on the last day of pregnancy does not indicate conducting gjs. It is suggested that gj conductance states, but not gj expression, are modulated by plasma estradiol titers. |
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Authors:
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Glenn I Hatton; Qin Zhao Yang |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 932 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 2002 Apr |
Date Detail:
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Created Date: 2002-03-25 Completed Date: 2002-06-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: Netherlands |
Other Details:
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Languages: eng Pagination: 120-3 Citation Subset: IM |
Affiliation:
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Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA. glenn.hatton@ucr.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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physiology Animals Female Interneurons / physiology* Lactation / physiology* Postpartum Period / physiology* Pregnancy Pregnancy, Animal / physiology* Rats Rats, Sprague-Dawley Supraoptic Nucleus / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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NS 16942/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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