Document Detail

Peripartum interneuronal coupling in the supraoptic nucleus.
MedLine Citation:
PMID:  11911868     Owner:  NLM     Status:  MEDLINE    
In the supraoptic nucleus (SON), the incidence of conducting gap junctions (gjs), as indicated by dye coupling, is low in cycling females, but dramatically elevated in nursing mothers. Functionally, this is consistent with the well-established presence of synchronous milk ejection bursts among oxytocin neurons only in the lactating rat. In situ hybridization data, however, revealed elevated gj mRNA expression on the last day of pregnancy, a time when burst firing by putative oxytocin neurons is absent. Using Lucifer Yellow dye coupling, we determined the incidence of high conductance gjs in SONs of proestrous, immediately prepartum, postpartum non-lactating, lactating day 1, and lactating day 9-10 rats. Results indicate that coupling incidence is high only at times when milk ejection bursts are known to occur, and that the elevated gj mRNA expression seen on the last day of pregnancy does not indicate conducting gjs. It is suggested that gj conductance states, but not gj expression, are modulated by plasma estradiol titers.
Glenn I Hatton; Qin Zhao Yang
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  932     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2002 Apr 
Date Detail:
Created Date:  2002-03-25     Completed Date:  2002-06-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  120-3     Citation Subset:  IM    
Department of Cell Biology and Neuroscience, University of California, Riverside, CA 92521, USA.
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MeSH Terms
Action Potentials / physiology
Interneurons / physiology*
Lactation / physiology*
Postpartum Period / physiology*
Pregnancy, Animal / physiology*
Rats, Sprague-Dawley
Supraoptic Nucleus / physiology*
Grant Support

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