Document Detail

Peripartum cardiomyopathy: a comprehensive review.
MedLine Citation:
PMID:  17208320     Owner:  NLM     Status:  MEDLINE    
Peripartum cardiomyopathy (PPCM) is a rare disorder in which left ventricular dysfunction and symptoms of heart failure occur in the peripartum period in previously healthy women. Incidence of PPCM ranges from 1 in 1300 to 1 in 15,000 pregnancies. The etiology of PPCM is unknown, but viral, autoimmune, and idiopathic causes may contribute. The diagnostic criteria are onset of heart failure in the last month of pregnancy or in first 5 months postpartum, absence of determinable cause for cardiac failure, and absence of a demonstrable heart disease before the last month of pregnancy. Risk factors for PPCM include advanced maternal age, multiparity, African race, twinning, gestational hypertension, and long-term tocolysis. The clinical presentation of patients with PPCM is similar to that of patients with dilated cardiomyopathy. Early diagnosis and initiation of treatment are essential to optimize pregnancy outcome. Treatment is similar to medical therapy for other forms of dilated cardiomyopathy. About half the patients of PPCM recover without complications. The prognosis is poor in patients with persistent cardiomyopathy. Persistence of disease after 6 months indicates irreversible cardiomyopathy and portends worse survival.
John Abboud; Yahya Murad; Carol Chen-Scarabelli; Louis Saravolatz; Tiziano M Scarabelli
Publication Detail:
Type:  Journal Article; Review     Date:  2007-01-17
Journal Detail:
Title:  International journal of cardiology     Volume:  118     ISSN:  1874-1754     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-05-08     Completed Date:  2007-07-23     Revised Date:  2008-07-31    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  295-303     Citation Subset:  IM    
Center for Heart and Vessel Preclinical Studies, Division of Cardiology, St John Hospital and Medical Center, Wayne State University, Detroit, MI 48236, USA.
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MeSH Terms
Cardiomyopathy, Dilated / diagnosis*,  drug therapy*
Cardiotonic Agents / therapeutic use
Drug Therapy, Combination
Postpartum Period
Pregnancy Complications, Cardiovascular / diagnosis*,  drug therapy*
Puerperal Disorders / diagnosis,  drug therapy,  epidemiology
Risk Factors
Severity of Illness Index
Treatment Outcome
Ventricular Dysfunction, Left / diagnosis,  drug therapy,  epidemiology
Reg. No./Substance:
0/Cardiotonic Agents
Comment In:
Int J Cardiol. 2008 Jun 23;127(1):142-3   [PMID:  17544526 ]
Int J Cardiol. 2008 Jun 23;127(1):144-5   [PMID:  18053591 ]

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