| Peripartum Clostridium difficile infection: case series and review of the literature. | |
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MedLine Citation:
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PMID: 18639213 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clostridium difficile infection (CDI) in nonhospitalized patients has been reported with increased frequency. An association between CDI and pregnancy has not been stressed. This review will report 4 cases of peripartum CDI with characterization of the infecting strain and a literature review. A PubMed search identified 24 recorded cases of peripartum CDI; information was available for 14 cases. Most patients (91%) received prophylactic antibiotics during delivery or for treatment of bacterial infections (50%). All patients reported diarrhea. Two of our reported cases without known risk factors were found by polymerase chain reaction analysis to be infected with an epidemic and hypervirulent C difficile strain. These cases demonstrate the need for clinicians to consider CDI in patients with severe diarrhea, even if they do not have the traditional risk factors for CDI, such as antibiotic use or concurrent hospitalizations. Further research into the scope and risk factors for peripartum CDI is warranted. |
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Authors:
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Kevin W Garey; Zhi-Dong Jiang; Yashoo Yadav; Bridget Mullins; Keith Wong; Herbert L Dupont |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2008-07-17 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 199 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2008-11-13 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 332-7 Citation Subset: AIM; IM |
Affiliation:
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Texas Medical Center, University of Houston College of Pharmacy, Houston, TX 77030, USA. kgarey@uh.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anti-Infective Agents / therapeutic use Clostridium difficile / genetics Enterocolitis, Pseudomembranous / diagnosis*, drug therapy, genetics Female Humans Length of Stay Metronidazole / therapeutic use Pregnancy Pregnancy Complications, Infectious / diagnosis*, drug therapy, genetics Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Infective Agents; 443-48-1/Metronidazole |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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