Document Detail

Peripartum Clostridium difficile infection: case series and review of the literature.
MedLine Citation:
PMID:  18639213     Owner:  NLM     Status:  MEDLINE    
Clostridium difficile infection (CDI) in nonhospitalized patients has been reported with increased frequency. An association between CDI and pregnancy has not been stressed. This review will report 4 cases of peripartum CDI with characterization of the infecting strain and a literature review. A PubMed search identified 24 recorded cases of peripartum CDI; information was available for 14 cases. Most patients (91%) received prophylactic antibiotics during delivery or for treatment of bacterial infections (50%). All patients reported diarrhea. Two of our reported cases without known risk factors were found by polymerase chain reaction analysis to be infected with an epidemic and hypervirulent C difficile strain. These cases demonstrate the need for clinicians to consider CDI in patients with severe diarrhea, even if they do not have the traditional risk factors for CDI, such as antibiotic use or concurrent hospitalizations. Further research into the scope and risk factors for peripartum CDI is warranted.
Kevin W Garey; Zhi-Dong Jiang; Yashoo Yadav; Bridget Mullins; Keith Wong; Herbert L Dupont
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2008-07-17
Journal Detail:
Title:  American journal of obstetrics and gynecology     Volume:  199     ISSN:  1097-6868     ISO Abbreviation:  Am. J. Obstet. Gynecol.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-20     Completed Date:  2008-11-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370476     Medline TA:  Am J Obstet Gynecol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  332-7     Citation Subset:  AIM; IM    
Texas Medical Center, University of Houston College of Pharmacy, Houston, TX 77030, USA.
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MeSH Terms
Anti-Infective Agents / therapeutic use
Clostridium difficile / genetics
Enterocolitis, Pseudomembranous / diagnosis*,  drug therapy,  genetics
Length of Stay
Metronidazole / therapeutic use
Pregnancy Complications, Infectious / diagnosis*,  drug therapy,  genetics
Risk Factors
Reg. No./Substance:
0/Anti-Infective Agents; 443-48-1/Metronidazole

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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