Document Detail


Periostin is a systemic biomarker of eosinophilic airway inflammation in asthmatic patients.
MedLine Citation:
PMID:  22857879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Eosinophilic airway inflammation is heterogeneous in asthmatic patients. We recently described a distinct subtype of asthma defined by the expression of genes inducible by T(H)2 cytokines in bronchial epithelium. This gene signature, which includes periostin, is present in approximately half of asthmatic patients and correlates with eosinophilic airway inflammation. However, identification of this subtype depends on invasive airway sampling, and hence noninvasive biomarkers of this phenotype are desirable.
OBJECTIVE: We sought to identify systemic biomarkers of eosinophilic airway inflammation in asthmatic patients.
METHODS: We measured fraction of exhaled nitric oxide (Feno), peripheral blood eosinophil, periostin, YKL-40, and IgE levels and compared these biomarkers with airway eosinophilia in asthmatic patients.
RESULTS: We collected sputum, performed bronchoscopy, and matched peripheral blood samples from 67 asthmatic patients who remained symptomatic despite maximal inhaled corticosteroid treatment (mean FEV(1), 60% of predicted value; mean Asthma Control Questionnaire [ACQ] score, 2.7). Serum periostin levels are significantly increased in asthmatic patients with evidence of eosinophilic airway inflammation relative to those with minimal eosinophilic airway inflammation. A logistic regression model, including sex, age, body mass index, IgE levels, blood eosinophil numbers, Feno levels, and serum periostin levels, in 59 patients with severe asthma showed that, of these indices, the serum periostin level was the single best predictor of airway eosinophilia (P = .007).
CONCLUSION: Periostin is a systemic biomarker of airway eosinophilia in asthmatic patients and has potential utility in patient selection for emerging asthma therapeutics targeting T(H)2 inflammation.
Authors:
Guiquan Jia; Richard W Erickson; David F Choy; Sofia Mosesova; Lawren C Wu; Owen D Solberg; Aarti Shikotra; Richard Carter; Séverine Audusseau; Qutayba Hamid; Peter Bradding; John V Fahy; Prescott G Woodruff; Jeffrey M Harris; Joseph R Arron;
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2012-08-01
Journal Detail:
Title:  The Journal of allergy and clinical immunology     Volume:  130     ISSN:  1097-6825     ISO Abbreviation:  J. Allergy Clin. Immunol.     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-08-31     Completed Date:  2012-11-07     Revised Date:  2014-04-08    
Medline Journal Info:
Nlm Unique ID:  1275002     Medline TA:  J Allergy Clin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  647-654.e10     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 American Academy of Allergy, Asthma & Immunology. Published by Mosby, Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adipokines / blood
Adult
Asthma / blood*,  drug therapy
Biological Markers
Breath Tests
Cell Adhesion Molecules / blood*
Eosinophilia / blood,  diagnosis*
Eosinophils / physiology
Female
Humans
Immunoglobulin E / blood
Inflammation / blood,  diagnosis*
Interleukin-13 / analysis,  physiology
Lectins / blood
Logistic Models
Male
Middle Aged
Nitric Oxide / analysis
Grant Support
ID/Acronym/Agency:
HL080414/HL/NHLBI NIH HHS; HL095372/HL/NHLBI NIH HHS; HL097591/HL/NHLBI NIH HHS; HL56385/HL/NHLBI NIH HHS; HL66564/HL/NHLBI NIH HHS; R01 HL095372/HL/NHLBI NIH HHS; R01 HL097591/HL/NHLBI NIH HHS; U10 HL109146/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Adipokines; 0/Biological Markers; 0/CHI3L1 protein, human; 0/Cell Adhesion Molecules; 0/Interleukin-13; 0/Lectins; 0/POSTN protein, human; 31C4KY9ESH/Nitric Oxide; 37341-29-0/Immunoglobulin E
Comments/Corrections

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