| Periostin, a matrix protein, is a novel biomarker for idiopathic interstitial pneumonias. | |
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MedLine Citation:
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PMID: 21177844 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Idiopathic interstitial pneumonias (IIPs) are histopathologically classified into several types, including usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP) and cryptogenic organising pneumonia (COP). We investigated whether periostin, a matrix protein, could be used as a biomarker to assess histopathological types of IIPs. We performed immunohistochemical analyses in each histopathological type of IIP, examined serum levels of periostin in IIP patients and analysed the relationship between serum levels of periostin and the pulmonary functions in patients with idiopathic pulmonary fibrosis (IPF). Periostin was strongly expressed in lungs of UIP and fibrotic NSIP patients, whereas expression of periostin was weak in the lungs of cellular NSIP and COP patients, as well as in normal lungs. Serum levels of periostin in IPF were significantly higher than those of healthy subjects and COP patients. Furthermore, periostin levels in IPF patients were inversely correlated with their pulmonary functions. Thus, we have found that periostin is a novel component of fibrosis in IIP. Periostin may be a potential biomarker to distinguish IIP with fibrosis. |
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Authors:
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M Okamoto; T Hoshino; Y Kitasato; Y Sakazaki; T Kawayama; K Fujimoto; K Ohshima; H Shiraishi; M Uchida; J Ono; S Ohta; S Kato; K Izuhara; H Aizawa |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-12-22 |
Journal Detail:
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Title: The European respiratory journal Volume: 37 ISSN: 1399-3003 ISO Abbreviation: Eur. Respir. J. Publication Date: 2011 May |
Date Detail:
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Created Date: 2011-05-02 Completed Date: 2011-08-31 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 8803460 Medline TA: Eur Respir J Country: Switzerland |
Other Details:
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Languages: eng Pagination: 1119-27 Citation Subset: IM |
Affiliation:
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Dept of Medicine, Kurume University School of Medicine, Kurume, Fukuoka, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Biological Markers / blood Cell Adhesion Molecules / blood* Female Humans Idiopathic Interstitial Pneumonias / blood*, pathology, physiopathology Lung / pathology, physiopathology Male Middle Aged |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Cell Adhesion Molecules; 0/POSTN protein, human |
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