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Periostin levels correlate disease severity and chronicity in patients with atopic dermatitis.
MedLine Citation:
PMID:  24601864     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Atopic dermatitis (AD) is a chronic inflammatory skin disease in which T helper 2 (Th2)-type immune responses are dominant. Keratinocytes persistently secrete proinflammatory cytokines and chemokines, amplifying Th2-type responses in AD. Recent findings indicate that periostin, an extracellular matrix protein induced by Th2 cytokines, plays a critical role in the pathogenesis of AD.
OBJECTIVE: To determine whether serum periostin level is associated with the clinical phenotype in adult AD patients.
METHODS: An enzyme-linked immunosorbent assay was performed to determine serum periostin levels in 257 adult AD patients, 66 patients with psoriasis vulgaris (PV) as a disease control and 25 healthy control subjects. Serum periostin levels were analysed together with clinical characteristics and laboratory parameters including thymus and activation-regulated chemokine (TARC), lactate dehydrogenase (LDH), blood eosinophil count and total immunoglobulin E (IgE). Immunohistochemical analysis was performed to evaluate periostin expression in association with various clinical phenotypes of AD. The effect of treatment on serum periostin level was also assessed.
RESULTS: Serum periostin was significantly higher in AD patients than in PV patients and healthy control subjects. The periostin level was found to be positively correlated with disease severity, TARC level, LDH level and eosinophil count, but not IgE level. Higher serum periostin level was observed in extrinsic AD patients compared to intrinsic AD patients, and the positive correlation of disease severity disappeared in patients with intrinsic AD. Robust expression of periostin was detected in the dermis of AD patients with erythroderma, lichenification and, to a lesser extent, scaly erythema. Serial measurement of serum periostin revealed decreased levels of periostin after treatment for AD.
CONCLUSIONS: The periostin level reflects disease severity and clinical phenotype of adult AD patients. Our results suggest that periostin may play a critical role in disease severity and chronicity in the pathogenesis of AD. This article is protected by copyright. All rights reserved.
Authors:
K Kou; T Okawa; Y Yamaguchi; J Ono; Y Inoue; M Kohno; S Matsukura; T Kambara; S Ohta; K Izuhara; M Aihara
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-3-6
Journal Detail:
Title:  The British journal of dermatology     Volume:  -     ISSN:  1365-2133     ISO Abbreviation:  Br. J. Dermatol.     Publication Date:  2014 Mar 
Date Detail:
Created Date:  2014-3-7     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0004041     Medline TA:  Br J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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