| Periorbital edema secondary to imatinib mesylate. | |
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MedLine Citation:
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PMID: 20505834 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Imatinib mesylate (Gleevec((R))) is a well-established pharmacologic treatment for all phases of chronic myeloid leukemia and for advanced gastrointestinal stromal tumors (GISTs). Edema-related side effects are relatively common in imatinib therapy with the periocular skin representing one of the most common sites for localized edema. While the adverse effect of periorbital edema with imatinib is well documented in the oncology literature, there is limited reference to this common reaction in the ophthalmology literature. We report two patients with upper eyelid edema associated with imatinib therapy who required surgical intervention to ameliorate significant visual field obstruction. We highlight the details of each case including the histopathologic findings of excised redundant skin followed by a thorough review of the literature on imatinib related periorbital edema. |
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Authors:
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Collin M McClelland; George J Harocopos; Philip L Custer |
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Publication Detail:
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Type: Journal Article Date: 2010-05-14 |
Journal Detail:
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Title: Clinical ophthalmology (Auckland, N.Z.) Volume: 4 ISSN: 1177-5483 ISO Abbreviation: Clin Ophthalmol Publication Date: 2010 |
Date Detail:
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Created Date: 2010-05-27 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101321512 Medline TA: Clin Ophthalmol Country: New Zealand |
Other Details:
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Languages: eng Pagination: 427-31 Citation Subset: - |
Affiliation:
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School of Medicine, Washington University, St. Louis, MO, USA. |
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