Document Detail

Periorbital cellulitis in the era of Haemophilus influenzae type B vaccine: predisposing factors and etiologic agents in hospitalized children.
MedLine Citation:
PMID:  18825903     Owner:  NLM     Status:  MEDLINE    
PURPOSE: The incidence of Haemophilus influenzae type B (HIB) infection, once the most common cause of periorbital cellulitis, declined dramatically after the introduction of HIB vaccine in 1990. The aim of the current study was to determine the predisposing factors and agents in the pathogenesis of periorbital cellulitis in hospitalized children in the post-HIB vaccination era. METHODS: Children with clinical findings of periorbital inflammation who were hospitalized in a tertiary pediatric hospital in Israel in 2000-2001 were observed prospectively. Special attention was directed to the predisposing medical condition in each case. RESULTS: One hundred sixty-three patients had a final discharge diagnosis of periorbital cellulitis. Mean age was 34 months (median = 24 months). The predisposing conditions were conjunctivitis (42.9%), infected wound or trauma (20.9%), insect bites (9.8%), sinusitis (8%), dacryostenosis (4.9%), and Streptococcus pneumoniae bacteremia (0.6%). Children with conjunctivitis and sinusitis had the most severe inflammatory signs. None of the cultures was positive for HIB, although only 71% of the children had complete immunization. CONCLUSION: The epidemiology of periorbital cellulitis in children has changed in the post-HIB vaccine era. The most common predisposing medical conditions are conjunctivitis or an infected wound in the vicinity of the eye. Bacteremia is rarely a source of the disease. These findings have important clinical implications in terms of choice of treatment.
Ayelet Rimon; Vered Hoffer; Dario Prais; Liora Harel; Jacob Amir
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pediatric ophthalmology and strabismus     Volume:  45     ISSN:  0191-3913     ISO Abbreviation:  J Pediatr Ophthalmol Strabismus     Publication Date:    2008 Sep-Oct
Date Detail:
Created Date:  2008-10-01     Completed Date:  2008-11-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7901143     Medline TA:  J Pediatr Ophthalmol Strabismus     Country:  United States    
Other Details:
Languages:  eng     Pagination:  300-4     Citation Subset:  IM    
Department of Pediatrics C, Schneider Children's Medical Center of Israel, Petah Tiqva.
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MeSH Terms
Child, Hospitalized / statistics & numerical data
Child, Preschool
Eye Infections, Bacterial / epidemiology,  microbiology*
Haemophilus Infections / prevention & control*
Haemophilus Vaccines / administration & dosage*
Haemophilus influenzae type b / isolation & purification*
Infant, Newborn
Israel / epidemiology
Orbital Cellulitis / epidemiology,  microbiology*
Risk Factors
Reg. No./Substance:
0/Haemophilus Vaccines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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