Document Detail

Perioperative statin therapy and renal outcomes after major vascular surgery: a propensity-based analysis.
MedLine Citation:
PMID:  18375322     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate how the presence and timing of statin therapy affect perioperative renal outcomes after major vascular surgery. DESIGN: Retrospective cohort study. SETTING: Surgical intensive care unit at a single academic medical center. PARTICIPANTS: Patients undergoing major vascular surgery between July 2004 and October 2005. MEASUREMENTS AND MAIN RESULTS: The presence and timing of perioperative statin administration and the propensity for receiving such therapy were noted. Renal outcomes, lengths of stay, and mortality were reviewed. One hundred fifty-one procedures were performed. Eighty-nine patients (59%) received statin therapy. There was no evidence for renal protection with perioperative statin therapy (Delta creatinine 0.2 mg/dL v 0.2 mg/dL, p = 0.41; acute renal injury/acute renal failure 8% v 6%, p = 1.00; renal replacement therapy 3% v 3%, p = 1.00; all statin v no statin, respectively). With the possible exception of early reinstitution of statin therapy in chronic statin users, subgroup analyses failed to confirm an association between statin timing and prevention of postoperative renal dysfunction. CONCLUSIONS: In the present investigation, neither the presence nor timing of perioperative statin therapy was associated with improved renal outcomes in patients undergoing a range of major vascular procedures. A possible exception is early postoperative reinitiation of statin therapy in chronic statin users. The discrepant results of available literature preclude a definitive statement on the use of statin therapy as a means of preventing postoperative renal dysfunction. An adequately powered prospective trial is needed before advocating the routine use of statin therapy for perioperative renal protection.
Daryl J Kor; Michael J Brown; Remzi Iscimen; Daniel R Brown; Francis X Whalen; Tuhin K Roy; Mark T Keegan
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of cardiothoracic and vascular anesthesia     Volume:  22     ISSN:  1532-8422     ISO Abbreviation:  J. Cardiothorac. Vasc. Anesth.     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-31     Completed Date:  2008-06-26     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110208     Medline TA:  J Cardiothorac Vasc Anesth     Country:  United States    
Other Details:
Languages:  eng     Pagination:  210-6     Citation Subset:  IM    
Department of Anesthesiology, Division of Critical Care, Mayo Clinic College of Medicine, Rochester, MN, USA.
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MeSH Terms
Aged, 80 and over
Cohort Studies
Hydroxymethylglutaryl-CoA Reductase Inhibitors / pharmacology,  therapeutic use*
Kidney Diseases / drug therapy,  etiology,  prevention & control*
Length of Stay / trends
Middle Aged
Perioperative Care / methods*
Postoperative Complications / drug therapy,  etiology,  prevention & control
Retrospective Studies
Treatment Outcome
Vascular Surgical Procedures* / adverse effects
Reg. No./Substance:
0/Hydroxymethylglutaryl-CoA Reductase Inhibitors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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