| Perioperative plasma concentrations of atrial and brain natriuretic peptides in patients undergoing hip arthroplasty. | |
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MedLine Citation:
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PMID: 12413257 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute hypotension, transient hypoxaemia and elevation of pulmonary artery pressure are well known to occur during cemented arthroplasty. The aim of this prospective clinical study was to characterize the relationship between plasma concentrations of atrial and brain natriuretic peptides (ANP, BNP), and changes in blood pressure in patients undergoing hip arthroplasty. Elevated ANP and BNP levels may be markers of inadequate myocardial reserve. We measured plasma ANP and BNP levels before the operation and 20 minutes after the cementing in 18 patients (54-90 yr). We defined a hypotensive response after cementing as a decrease in systolic blood pressure of more than 15 mm Hg below the pre-cementing value. In the hypotensive group, preoperative values of ANP were 123 +/- 48.5 pg/ml and BNP, 138 +/- 71.7 pg/ml. These values are significantly greater than those in the normotensive group (ANP 35.9 +/- 7.7, and BNP 17.2 +/- 3.2 pg/ml). High preoperative values of ANP and BNP are associated with more hypotension during cemented arthroplasty and could provide an indication of which patients are at risk of this complication. |
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Authors:
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K Terasako |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Anaesthesia and intensive care Volume: 30 ISSN: 0310-057X ISO Abbreviation: Anaesth Intensive Care Publication Date: 2002 Oct |
Date Detail:
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Created Date: 2002-11-04 Completed Date: 2003-02-14 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0342017 Medline TA: Anaesth Intensive Care Country: Australia |
Other Details:
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Languages: eng Pagination: 588-90 Citation Subset: IM |
Affiliation:
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Division of Anesthesia, Kyoto Katsura Hospital, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Analysis of Variance Anesthesia, Intravenous / methods Anesthetics, Combined Arthroplasty, Replacement, Hip / adverse effects, methods* Atrial Natriuretic Factor / blood* Biological Markers / analysis Blood Pressure Determination Bone Cements Female Follow-Up Studies Hemodynamics / drug effects Humans Hypotension / diagnosis*, epidemiology Male Middle Aged Natriuretic Peptide, Brain / blood* Perioperative Care Probability Propofol / administration & dosage Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics, Combined; 0/Biological Markers; 0/Bone Cements; 114471-18-0/Natriuretic Peptide, Brain; 2078-54-8/Propofol; 85637-73-6/Atrial Natriuretic Factor |
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