Document Detail

Perioperative plasma concentrations of atrial and brain natriuretic peptides in patients undergoing hip arthroplasty.
MedLine Citation:
PMID:  12413257     Owner:  NLM     Status:  MEDLINE    
Acute hypotension, transient hypoxaemia and elevation of pulmonary artery pressure are well known to occur during cemented arthroplasty. The aim of this prospective clinical study was to characterize the relationship between plasma concentrations of atrial and brain natriuretic peptides (ANP, BNP), and changes in blood pressure in patients undergoing hip arthroplasty. Elevated ANP and BNP levels may be markers of inadequate myocardial reserve. We measured plasma ANP and BNP levels before the operation and 20 minutes after the cementing in 18 patients (54-90 yr). We defined a hypotensive response after cementing as a decrease in systolic blood pressure of more than 15 mm Hg below the pre-cementing value. In the hypotensive group, preoperative values of ANP were 123 +/- 48.5 pg/ml and BNP, 138 +/- 71.7 pg/ml. These values are significantly greater than those in the normotensive group (ANP 35.9 +/- 7.7, and BNP 17.2 +/- 3.2 pg/ml). High preoperative values of ANP and BNP are associated with more hypotension during cemented arthroplasty and could provide an indication of which patients are at risk of this complication.
K Terasako
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  30     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-11-04     Completed Date:  2003-02-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  588-90     Citation Subset:  IM    
Division of Anesthesia, Kyoto Katsura Hospital, Japan.
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MeSH Terms
Aged, 80 and over
Analysis of Variance
Anesthesia, Intravenous / methods
Anesthetics, Combined
Arthroplasty, Replacement, Hip / adverse effects,  methods*
Atrial Natriuretic Factor / blood*
Biological Markers / analysis
Blood Pressure Determination
Bone Cements
Follow-Up Studies
Hemodynamics / drug effects
Hypotension / diagnosis*,  epidemiology
Middle Aged
Natriuretic Peptide, Brain / blood*
Perioperative Care
Propofol / administration & dosage
Sensitivity and Specificity
Reg. No./Substance:
0/Anesthetics, Combined; 0/Biological Markers; 0/Bone Cements; 114471-18-0/Natriuretic Peptide, Brain; 2078-54-8/Propofol; 85637-73-6/Atrial Natriuretic Factor

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