Document Detail

Perioperative plasma brain natriuretic peptide and cardiotrophin-1 in off-pump coronary artery bypass.
MedLine Citation:
PMID:  18609050     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: It has been suggested that brain natriuretic peptide (BNP) and cardiotrophin-1 (CT-1) are associated with myocardial dysfunction. The present prospective study was designed to investigate perioperative changes of plasma levels of BNP and CT-1 in off-pump coronary artery bypass (OPCAB). METHOD: Forty-nine patients undergoing elective OPCAB were divided into three groups. Group I: no previous myocardial infarction; Group II: previous myocardial infarction more than 12 weeks; Group III: recent myocardial infarction within 4-8 weeks. Perioperative BNP and CT-1 levels were measured, and hematochemical parameters were also collected. RESULTS: Higher preoperative BNP and CT-1 levels were found in group III as compared to those in group I. BNP levels increased after operation, and reached peak value at 3-7 days after the operation. However, the postoperative changes of BNP levels were not different among groups in any time points. CT-1 levels did not change significantly after the operation as compared to baseline. CONCLUSION: Higher BNP and CT-1 levels were associated with recent myocardial infarction. BNP elevated after OPCAB, but CT-1 showed no significant postoperative changes. Postoperative changes of BNP and CT-1 do not associated with cardiac function in OPCAB.
Minxin Wei; Shuo Ren; Jianshi Liu; Peijun Li; Hongyu Qian; Matti Tarkka
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Scandinavian cardiovascular journal : SCJ     Volume:  42     ISSN:  1651-2006     ISO Abbreviation:  Scand. Cardiovasc. J.     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-03     Completed Date:  2009-02-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9708377     Medline TA:  Scand Cardiovasc J     Country:  England    
Other Details:
Languages:  eng     Pagination:  399-404     Citation Subset:  IM    
Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, P. R. China.
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MeSH Terms
Biological Markers / blood
Coronary Artery Bypass, Off-Pump*
Coronary Artery Disease / blood,  complications,  physiopathology,  surgery*
Cytokines / blood*
Middle Aged
Myocardial Infarction / blood,  etiology*,  physiopathology,  surgery
Natriuretic Peptide, Brain / blood*
Perioperative Care
Prospective Studies
Time Factors
Ventricular Function, Left
Reg. No./Substance:
0/Biological Markers; 0/Cytokines; 0/cardiotrophin 1; 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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