| Perioperative normothermia depends on intraoperative warming procedure, extent of the surgical intervention and age of the experimental animal. | |
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MedLine Citation:
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PMID: 15979105 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The maintenance of a physiological body temperature during and early after surgical interventions in experimental animals such as rodents is often neglected. Therefore the positive influence of an adequate use of warming blankets (WB) on the rectal body temperature in rats was investigated during two different surgical interventions, with a special focus on possible differences between young adult (2.5+/-0.14 months) and adult animals (9.3+/-0.13 months). Anesthesia was induced with isoflurane short inhalation and maintained with ketamine and domitor intramuscularly. Animals were divided into ten groups according to (a) the age of the animals, (b) the temperature of the WB and (c) the kind of surgical intervention (either an intravenous [i.v.] cannulation of the right external jugular vein or an intra-aortal implantation of a telemetric transmitter or both). Results clearly show that the surface temperature of the WB has a major impact on the perioperative thermoregulation. The rectal body temperature of animals operated on a cooler WB dramatically decreased depending on the age of the rat and also on the extent of the surgical intervention. The opening of the abdominal cavity in older rats resulted in a severe hypothermia: they lost 5.6 degrees C compared to 3.2 degrees C in the young adult rats. The implantation of the i.v. catheter had no serious effect on the thermoregulation. In conclusion, the results clearly show that an adequate perioperative warming system positively influences the postoperative outcome in young adult and most notably in adult rats and thus enables early postoperative experiments without effects on measured parameters. |
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Authors:
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Melanie Felies; Sonja Poppendieck; Heike Nave |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2005-06-23 |
Journal Detail:
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Title: Life sciences Volume: 77 ISSN: 0024-3205 ISO Abbreviation: Life Sci. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-10-11 Completed Date: 2005-11-10 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375521 Medline TA: Life Sci Country: England |
Other Details:
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Languages: eng Pagination: 3133-40 Citation Subset: IM |
Affiliation:
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Department of Functional and Applied Anatomy, Hannover Medical School, Carl-Neuberg-Str.1, 30625 Hannover, Germany. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aging
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physiology* Animals Body Temperature / physiology Hypothermia / etiology, prevention & control* Intraoperative Period Kinetics Male Rats Rats, Inbred Lew Rewarming / methods* Surgical Procedures, Operative* |
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