Document Detail

Perioperative fluid management: comparison of high, medium and low fluid volume on tissue oxygen pressure in the small bowel and colon.
MedLine Citation:
PMID:  17582246     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Insufficient blood flow and oxygenation in the intestinal tract is associated with increased incidence of postoperative complications after bowel surgery. High fluid volume administration may prevent occult regional hypoperfusion and intestinal tissue hypoxia. We tested the hypothesis that high intraoperative fluid volume administration increases intestinal wall tissue oxygen pressure during laparotomy. METHODS: In all, 27 pigs were anaesthetized, ventilated and randomly assigned to one of the three treatment groups (n = 9 in each) receiving low (3 mL kg-1 h-1), medium (7 mL kg-1 h-1) or high (20 mL kg-1 h-1) fluid volume treatment with lactated Ringer's solution. All animals received 30% and 100% inspired oxygen in random order. Cardiac index was measured with thermodilution and tissue oxygen pressure with a micro-oximetry system in the jejunum and colon wall and subcutaneous tissue. RESULTS: Groups receiving low and medium fluid volume treatment had similar systemic haemodynamics. The high fluid volume group had significantly higher mean arterial pressure, cardiac index and subcutaneous tissue oxygenation. Tissue oxygen pressures in the jejunum and colon were comparable in all three groups. CONCLUSIONS: The three different fluid volume regimens tested did not affect tissue oxygen pressure in the jejunum and colon, suggesting efficient autoregulation of intestinal blood flow in healthy subjects undergoing uncomplicated abdominal surgery.
L B Hiltebrand; G Pestel; H Hager; J Ratnaraj; G H Sigurdsson; A Kurz
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-06-21
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  24     ISSN:  0265-0215     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2007 Nov 
Date Detail:
Created Date:  2007-10-09     Completed Date:  2008-01-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  927-33     Citation Subset:  IM    
Washington University, Department of Anesthesiology, St. Louis, MO, USA.
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MeSH Terms
Blood Volume / physiology
Body Temperature / physiology
Carbon Dioxide / blood
Colon / metabolism*
Fluid Therapy*
Hydrogen-Ion Concentration
Hypovolemia / prevention & control
Intestine, Small / metabolism*
Isotonic Solutions / administration & dosage
Oxygen / blood*
Oxygen Consumption / physiology
Perioperative Care
Plasma Substitutes / administration & dosage
Respiratory Mechanics / physiology
Grant Support
Reg. No./Substance:
0/Isotonic Solutions; 0/Plasma Substitutes; 0/crystalloid solutions; 124-38-9/Carbon Dioxide; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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