Document Detail

Perioperative changes in superoxide production in neonates and infants.
MedLine Citation:
PMID:  8281593     Owner:  NLM     Status:  MEDLINE    
We conducted a prospective study to investigate perioperative changes in the production of superoxide anion (O2-) by neutrophils isolated from ten neonates between the ages of five and 16 days (N group) and ten infants ranging in age from one to ten months (I group). They underwent abdominal surgery under general anaesthesia with halothane and nitrous oxide in oxygen. The O2- production (speed and amount) was measured perioperatively using the cytochrome c reduction method. Both groups showed a decrease in the speed and amount of O2- production during and after surgery. The decrease in O2- production reached its lowest level three hours postoperatively or at the end of surgery in both groups. The O2- production in the I group returned to the basal value 48 hr postoperatively. In contrast, the O2- production in the N group was still lower 48 hr after surgery than before anaesthesia. Although the total amount of O2- production by neutrophils in one mL of peripheral blood remained unchanged in the I group, the total amount of O2- production in the N group decreased at the end of surgery and thereafter. These data indicate that even relatively minor abdominal surgery with halothane anaesthesia may be associated with perioperative neutrophil impairment in both neonates and infants. This impairment of neutrophil function in infants but not in neonates may be compensated by an increase in neutrophil numbers. It is possible that perioperative susceptibility of neonates to bacterial infections is attributable, at least in part, to the inhibition of O2- production in neutrophils by surgery and general anaesthesia.
K Mikawa; K Nishina; N Maekawa; H Yaku; H Obara; Y Uetani; H Nakamura
Related Documents :
14640153 - A survey of sodium hypochlorite use by general dental practitioners and endodontists in...
1148073 - Deaths associated with anaesthesia.
3097293 - Enhanced lipid utilization in infants receiving oral l-carnitine during long-term paren...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Canadian journal of anaesthesia = Journal canadien d'anesthésie     Volume:  40     ISSN:  0832-610X     ISO Abbreviation:  Can J Anaesth     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-02-17     Completed Date:  1994-02-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8701709     Medline TA:  Can J Anaesth     Country:  CANADA    
Other Details:
Languages:  eng     Pagination:  1162-70     Citation Subset:  IM    
Department of Anaesthesiology, Kobe University School of Medicine, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Abdomen / surgery*
Anesthesia, Inhalation
Infant, Newborn
Intraoperative Period
Leukocyte Count
N-Formylmethionine Leucyl-Phenylalanine / pharmacology
Neutrophils / cytology,  metabolism*
Nitrous Oxide
Oxygen / blood
Oxygen Consumption
Postoperative Period
Prospective Studies
Sensitivity and Specificity
Superoxides / analysis,  blood*
Tetradecanoylphorbol Acetate / pharmacology
Reg. No./Substance:
10024-97-2/Nitrous Oxide; 11062-77-4/Superoxides; 151-67-7/Halothane; 16561-29-8/Tetradecanoylphorbol Acetate; 59880-97-6/N-Formylmethionine Leucyl-Phenylalanine; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A single i.v. dose of ondansetron 8 mg prior to induction of anaesthesia reduces postoperative nause...
Next Document:  Anaesthesia for adenotonsillectomy: a comparison between tracheal intubation and the armoured laryng...