| Perioperative central nervous system injury in neonates. | |
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MedLine Citation:
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PMID: 23242752 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Anaesthetic-induced developmental neurotoxicity (AIDN) has been clearly established in laboratory animal models. The possibility of neurotoxicity during uneventful anaesthetic procedures in human neonates or infants has led to serious questions about the safety of paediatric anaesthesia. However, the applicability of animal data to clinical anaesthesia practice remains uncertain. The spectre of cerebral injury due to cerebral hypoperfusion, metabolic derangements, coexisting disease, and surgery itself further muddles the picture. Given the potential magnitude of the public health importance of this issue, the clinician should be cognisant of the literature and ongoing investigations on AIDN, and raise awareness of the risks of both surgery and anaesthesia. |
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Authors:
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M E McCann; S G Soriano |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: British journal of anaesthesia Volume: 109 Suppl 1 ISSN: 1471-6771 ISO Abbreviation: Br J Anaesth Publication Date: 2012 Dec |
Date Detail:
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Created Date: 2012-12-17 Completed Date: 2013-03-25 Revised Date: 2013-04-16 |
Medline Journal Info:
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Nlm Unique ID: 0372541 Medline TA: Br J Anaesth Country: England |
Other Details:
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Languages: eng Pagination: i60-i67 Citation Subset: IM |
Affiliation:
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Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA 02115, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, General
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adverse effects* Anesthetics / adverse effects*, toxicity* Body Temperature Regulation Brain / drug effects*, growth & development* Brain Injuries / chemically induced, physiopathology Child Development / drug effects Heart Defects, Congenital / physiopathology, surgery Humans Hypocapnia / physiopathology Hypotension / physiopathology Infant, Newborn Learning Disorders / etiology Perioperative Period |
| Grant Support | |
ID/Acronym/Agency:
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1-R01 HD 061136-01A1/HD/NICHD NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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