Document Detail


Perioperative central nervous system injury in neonates.
MedLine Citation:
PMID:  23242752     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anaesthetic-induced developmental neurotoxicity (AIDN) has been clearly established in laboratory animal models. The possibility of neurotoxicity during uneventful anaesthetic procedures in human neonates or infants has led to serious questions about the safety of paediatric anaesthesia. However, the applicability of animal data to clinical anaesthesia practice remains uncertain. The spectre of cerebral injury due to cerebral hypoperfusion, metabolic derangements, coexisting disease, and surgery itself further muddles the picture. Given the potential magnitude of the public health importance of this issue, the clinician should be cognisant of the literature and ongoing investigations on AIDN, and raise awareness of the risks of both surgery and anaesthesia.
Authors:
M E McCann; S G Soriano
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  109 Suppl 1     ISSN:  1471-6771     ISO Abbreviation:  Br J Anaesth     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-17     Completed Date:  2013-03-25     Revised Date:  2013-12-04    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  England    
Other Details:
Languages:  eng     Pagination:  i60-i67     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Anesthesia, General / adverse effects*
Anesthetics / adverse effects*,  toxicity*
Body Temperature Regulation
Brain / drug effects*,  growth & development*
Brain Injuries / chemically induced,  physiopathology
Child Development / drug effects
Heart Defects, Congenital / physiopathology,  surgery
Humans
Hypocapnia / physiopathology
Hypotension / physiopathology
Infant, Newborn
Learning Disorders / etiology
Perioperative Period
Grant Support
ID/Acronym/Agency:
1-R01 HD 061136-01A1/HD/NICHD NIH HHS
Chemical
Reg. No./Substance:
0/Anesthetics
Comments/Corrections

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