Document Detail

Perioperative beta-blockade: might the baby go out with the bath water?
MedLine Citation:
PMID:  25468844     Owner:  NLM     Status:  In-Data-Review    
Perioperative β-blocker therapy has been advocated to reduce cardiac mortality and morbidity in high-risk cardiac patients undergoing non-cardiac surgery. Core data that supported this intervention and informed international societal guidelines has recently been withdrawn. A subsequent meta-analysis of the remaining data reporting excess mortality has re-opened the debate about the utility of β-blocker therapy in the perioperative period. Criticism of remaining trial designs and new insights into the protective mechanisms of β-blocker therapy in critical illness raise important questions that should now be addressed by a further robust, high-quality randomised control trial.
Ravin Mistry; David Walker
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical medicine (London, England)     Volume:  14     ISSN:  1470-2118     ISO Abbreviation:  Clin Med     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092853     Medline TA:  Clin Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  604-7     Citation Subset:  IM    
Copyright Information:
© 2014 Royal College of Physicians.
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