Document Detail

Perioperative beta blockade in noncardiac surgery: a review of the literature.
MedLine Citation:
PMID:  16617914     Owner:  NLM     Status:  MEDLINE    
Perioperative beta blockade has been proven to significantly reduce the incidence of myocardial ischemia and myocardial infarction and of long-term overall mortality related to cardiac events after various surgeries in patients at intermediate or high risk for such events. The major physiologic effects of beta blockers result in a positive balance of myocardial oxygen supply and demand. Although the optimal time frame for initiation of treatment is not clear from the available data, it has been shown that beta blocker therapy is effective when started at least 1 week before the scheduled surgery and continued throughout the postoperative period. The current recommendations for perioperative beta blockade for patients at intermediate and high risk for a perioperative cardiac event are to use a beta1 blocking agent, begin therapy several weeks before a planned operation, titrate the dose to achieve a heart rate of 60 to 70 beats per minute, and taper the dose of the beta blocker after the postoperative period.
Kimberly E Mason; Liana L Davis
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  AANA journal     Volume:  74     ISSN:  0094-6354     ISO Abbreviation:  AANA J     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-18     Completed Date:  2006-05-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0431420     Medline TA:  AANA J     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  N    
Lancaster General Hospital, PA, USA.
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MeSH Terms
Adrenergic beta-Antagonists / contraindications,  pharmacology,  therapeutic use*
Drug Administration Schedule
Drug Monitoring
Evidence-Based Medicine
Heart Rate
Myocardial Infarction / epidemiology,  etiology,  prevention & control*
Myocardial Ischemia / epidemiology,  etiology,  prevention & control*
Patient Selection
Perioperative Care / methods*
Postoperative Complications / etiology,  prevention & control*
Practice Guidelines as Topic
Randomized Controlled Trials as Topic
Risk Factors
Time Factors
Treatment Outcome
United States / epidemiology
Reg. No./Substance:
0/Adrenergic beta-Antagonists

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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