Document Detail


Perioperative assessment of coagulation in paediatric neurosurgical patients using thromboelastography.
MedLine Citation:
PMID:  19401660     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND OBJECTIVE: Primary brain tumours may be associated with coagulation disorders, which can pose intraoperative and postoperative management difficulties. Thromboelastography is a useful technique for evaluating coagulability. In this study, we evaluated the perioperative coagulation profile using both standard laboratory work and thromboelastography in paediatric patients undergoing craniotomy for primary brain tumours. METHODS: Forty paediatric patients were enrolled in the study. All patients received standard anaesthesia. Blood was analysed for both standard laboratory analysis and thromboelastography at three points for each patient: preoperatively, intraoperatively and postoperatively. Postoperative patients were divided into two groups according to the occurrence or nonoccurrence of postoperative haematomas: nonhaematoma group and haematoma group. The standard blood analysis and thromboelastography values for both groups were compared. RESULTS: Perioperative standard blood analysis was within normal limits for all patients, with no significant difference between both groups. In the nonhaematoma group, thromboelastography values were indicative of a hypercoagulable state that started intraoperatively and continued into the first postoperative day. In the haematoma group, thromboelastography values were indicative of a hypocoagulable state that was evident in the preoperative thromboelastography values and continued into the intraoperative as well as the postoperative period. CONCLUSION: Thromboelastography may be useful in the perioperative assessment and monitoring of coagulation in paediatric neurosurgical patients and helps in identifying patients at increased risk of bleeding or thromboembolic events.
Authors:
Nahla El Kady; Hisham Khedr; Mohammad Yosry; Sherief El Mekawi
Publication Detail:
Type:  Evaluation Studies; Journal Article    
Journal Detail:
Title:  European journal of anaesthesiology     Volume:  26     ISSN:  1365-2346     ISO Abbreviation:  Eur J Anaesthesiol     Publication Date:  2009 Apr 
Date Detail:
Created Date:  2009-04-29     Completed Date:  2009-08-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8411711     Medline TA:  Eur J Anaesthesiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  293-7     Citation Subset:  IM    
Affiliation:
Department of Anesthesia, Faculty of Medicine, Cairo University, Cairo, Egypt.
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MeSH Terms
Descriptor/Qualifier:
Blood Coagulation*
Brain Neoplasms / surgery*
Child
Craniotomy*
Female
Hematoma / blood
Humans
Male
Perioperative Care / methods
Thrombelastography*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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