Document Detail

Perioperative analgesia of infants during the therapy for retinopathy of prematurity.
MedLine Citation:
PMID:  20357717     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: In this retrospective investigation, we compared the main anesthesiologic aspects in the preoperative, perioperative, and postoperative care of 2 different surgical methods (cryotherapy, laser coagulation) for retinopathy of prematurity.
MATERIAL/METHODS: A retrospective analysis of analgesia for retinopathy of prematurity was performed for a 14-year period. Infants treated from January 1994 to December 2007 were involved in the study. Before 1997, we performed transconjunctival cryotherapy with ketamine analgesia for 28 newborn infants, while in the last 10 years, laser photocoagulation was done with nalbuphine-diazepam analgesia in 85 cases.
RESULTS: Significant differences were verified in gestational age of birth in the group of retinopathy of prematurity patients treated with cryotherapy compared with those treated with laser coagulation 27.9+/-2.7 weeks vs 26.4+/-2.4 weeks (P<.05). The difference in the need for postoperative ventilation (43% vs 19%; P<.05) as well as the number of cases with hypoxemia (54% vs 21%; P<.05) was significant, compared with the group of infants treated with cryotherapy with those treated with laser coagulation.
CONCLUSIONS: This study demonstrates that intravenous analgesia (with ketamine or nalbuphine-diazepam) can be used in the surgical treatment of retinopathy of prematurity.
Eva Görbe; Rita Vámos; Gabor József Joó; Judit Jeager; Attila Molvarec; Botond Berecz; Adrienn Horváth; Balint Sulya; János Rigó
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Medical science monitor : international medical journal of experimental and clinical research     Volume:  16     ISSN:  1643-3750     ISO Abbreviation:  Med. Sci. Monit.     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-01     Completed Date:  2010-08-05     Revised Date:  2011-06-14    
Medline Journal Info:
Nlm Unique ID:  9609063     Medline TA:  Med Sci Monit     Country:  Poland    
Other Details:
Languages:  eng     Pagination:  CR186-189     Citation Subset:  IM    
1st Department of Obstetrics and Gynecology, Semmelweis University, Faculty of Medicine, 1088 Budapest, Hungary.
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MeSH Terms
Analgesia / methods*
Anesthesiology / methods
Cryotherapy / methods
Diazepam / therapeutic use
Infant, Newborn
Ketamine / therapeutic use
Laser Coagulation / methods
Nalbuphine / therapeutic use
Postoperative Period
Preoperative Period
Retinopathy of Prematurity / therapy*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
20594-83-6/Nalbuphine; 439-14-5/Diazepam; 6740-88-1/Ketamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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