| Perioperative pregabalin improves pain and functional outcomes 3 months after lumbar discectomy. | |
| | |
MedLine Citation:
|
PMID: 20103545 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Patient outcome after lumbar discectomy for radicular low back pain is variable and the benefit is inconsistent. Many patients continue to experience pain 3 months after surgery. Pregabalin, a membrane stabilizer, may decrease perioperative central sensitization and subsequent persistent pain. METHODS: Forty patients undergoing lumbar discectomy were randomly allocated to receive either pregabalin (300 mg at 90 minutes preoperatively and 150 mg at 12 and 24 hours postoperatively) or placebo at corresponding times in a double-blinded manner. Our primary outcome was the change in the present pain intensity (PPI) (visual analog scale [VAS], 0-100 mm [PPI-VAS, McGill Pain Questionnaire]) from preoperatively to 3 months postoperatively. RESULTS: The decrease in PPI-VAS score at 3 months was greater in patients who received pregabalin (37.6 +/- 19.6 mm) (mean +/- sd) than those who received placebo (25.3 +/- 21.9 mm) (P = 0.08). The Roland Morris disability score at 3 months was less in patients who received pregabalin (2.7 +/- 2.4) than in those who received placebo (5.6 +/- 4.8) (P = 0.032). Pregabalin administration was associated with greater pain tolerance thresholds in both lower limbs compared with placebo at 24 hours postoperatively. CONCLUSION: Perioperative pregabalin administration is associated with less pain intensity and improved functional outcomes 3 months after lumbar discectomy. |
| | |
Authors:
|
Siun M Burke; George D Shorten |
Related Documents
:
|
2666455 - Ibuprofen and acetaminophen in the relief of postpartum episiotomy pain. 20347835 - Effects of sp6 acupressure on pain and menstrual distress in young women with dysmenorr... 2250925 - The influence of warning signal timing and cognitive preparation on the aversiveness of... 22092585 - Randomized trials for the treatment of burning mouth syndrome: an evidence-based review... 22835395 - Nonoperative management of retrocalcaneal pain with afo and stretching regimen. 1293205 - A holistic approach to vaso-occlusive pain crisis in children with sickle cell disease. |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't Date: 2010-01-26 |
Journal Detail:
|
Title: Anesthesia and analgesia Volume: 110 ISSN: 1526-7598 ISO Abbreviation: Anesth. Analg. Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-01 Completed Date: 2010-04-23 Revised Date: 2010-05-28 |
Medline Journal Info:
|
Nlm Unique ID: 1310650 Medline TA: Anesth Analg Country: United States |
Other Details:
|
Languages: eng Pagination: 1180-5 Citation Subset: AIM; IM |
Affiliation:
|
Department of Anaesthesia and Intensive Care Medicine, Cork University Hospital, Wilton, Cork, Ireland. siunburke@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Analgesics / adverse effects, therapeutic use* Anesthesia DNA / genetics Diskectomy* Double-Blind Method Electric Stimulation Female Hemodynamics / physiology Humans Male Middle Aged Pain Measurement / drug effects Pain Threshold / drug effects Pain, Postoperative / drug therapy* Receptors, Opioid, mu / genetics Reverse Transcriptase Polymerase Chain Reaction Treatment Outcome Young Adult gamma-Aminobutyric Acid / adverse effects, analogs & derivatives*, therapeutic use |
| Chemical | |
Reg. No./Substance:
|
0/Analgesics; 0/OPRM1 protein, human; 0/Receptors, Opioid, mu; 0/pregabalin; 56-12-2/gamma-Aminobutyric Acid; 9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Esmolol and Landiolol, Selective {beta}1-Adrenoreceptor Antagonists, Provide Neuroprotection Against...
Next Document: Kallikreins on Steroids: Structure, Function, and Hormonal Regulation of Prostate-Specific Antigen a...