| Perioperative blood transfusions promote pancreas cancer progression. | |
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MedLine Citation:
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PMID: 20828757 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Complex abdominal procedures to extirpate malignancies are often associated with blood transfusion. In particular, perioperative transfusion rates for pancreaticoduodenectomy can be as high as 75%. In the early 1970s it was shown that blood transfusions likely had immunomodulating effects as renal allografts were found to have longer survival in patients who received multiple transfusions. Subsequently, it has been suggested that blood transfusions may promote cancer progression. Many retrospective series have supported this hypothesis, and recent studies examining long-term survival in patients undergoing "Whipple" procedures suggests that transfusion is a negative prognostic factor. Despite these studies, the claim that transfusion is a simple surrogate for patient health, tumor size, location, and biology are difficult to refute. The use of syngeneic murine models has allowed many confounding variables to be controlled, and suggest that transfusion does indeed promote pancreas cancer progression. Based on these findings, as well as the continued need for blood transfusion, alternate strategies in transfusion management are warranted. |
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Authors:
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Douglas Benson; Carlton C Barnett |
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Publication Detail:
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Type: Journal Article Date: 2010-06-16 |
Journal Detail:
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Title: The Journal of surgical research Volume: 166 ISSN: 1095-8673 ISO Abbreviation: J. Surg. Res. Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-03-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376340 Medline TA: J Surg Res Country: United States |
Other Details:
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Languages: eng Pagination: 275-9 Citation Subset: IM |
Copyright Information:
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Copyright © 2011 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Surgery, Denver Health Medical Center, University of Colorado at Denver, Colorado. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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