| Periods of recovery in deficit syndrome schizophrenia: a 20-year multi-follow-up longitudinal study. | |
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MedLine Citation:
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PMID: 19095758 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Periods of recovery were examined in patients with and without deficit syndrome schizophrenia. Fifty-six patients with schizophrenia were studied, 39 of whom were divided into deficit and nondeficit syndrome schizophrenia subtypes using a proxy method. We also studied 39 nonpsychotic depressive comparison patients. Patients were evaluated as part of the Chicago Follow-up Study, which prospectively examined patients at regular intervals over a 20-year period. Using standardized instruments, patients were evaluated for the deficit syndrome, global recovery, rehospitalization, social dysfunction, occupational disability, and symptom presentation. Recovery was examined at 6 time points measured at 2-, 4.5-, 7.5-, 10-, 15-, and 20-year postindex hospitalization. Cumulatively, over the 20-year period, 13% of patients classified as meeting criteria for the deficit syndrome showed 1 or more 1-year periods of global recovery, in comparison to 63% of nondeficit schizophrenia patients and 77% of depressed patient controls. Results indicate that the deficit syndrome represents a persistently impaired subsample of schizophrenia patients, with continuous social, occupational, and symptom impairment. In contrast, nondeficit syndrome schizophrenia patients showed at least some periods of remission or recovery, with the likelihood of these periods increasing as they became older. Findings provide further support for the validity of the deficit syndrome concept and suggest that deficit status is characterized by a more persistently impaired course of illness and particularly poor long-term prognosis. |
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Authors:
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Gregory P Strauss; Martin Harrow; Linda S Grossman; Cherise Rosen |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural Date: 2008-12-18 |
Journal Detail:
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Title: Schizophrenia bulletin Volume: 36 ISSN: 1745-1701 ISO Abbreviation: Schizophr Bull Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-10-22 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0236760 Medline TA: Schizophr Bull Country: United States |
Other Details:
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Languages: eng Pagination: 788-99 Citation Subset: IM |
Affiliation:
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Department of Psychiatry, University of Illinois Medical Center, Chicago, IL, USA. gstrauss@mprc.umaryland.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affective Symptoms / classification, diagnosis*, psychology, rehabilitation Age Factors Antipsychotic Agents / therapeutic use Depressive Disorder / classification, diagnosis, psychology Female Humans Longitudinal Studies Male Middle Aged Patient Readmission Psychiatric Status Rating Scales / statistics & numerical data* Psychometrics Reference Values Rehabilitation, Vocational Schizophrenia / classification, diagnosis*, rehabilitation Schizophrenic Psychology* Social Adjustment Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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MH-068688/MH/NIMH NIH HHS; MH-26341/MH/NIMH NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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