| Periodontitis, a marker of risk in pregnancy for preterm birth. | |
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MedLine Citation:
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PMID: 15642058 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Why chronic periodontitis may induce an inflammatory response with premature pregnancy termination is unclear. AIMS: (1) To assess if periodontitis predicts premature gestation; (2) to study amniotic fluid cytokines and periodontitis variables in early-stage pregnancy. MATERIAL AND METHODS: A periodontal examination and collection of amniotic fluid was performed (weeks 15-20) of pregnancy in 36 women at risk for pregnancy complications. Amniotic fluid (bacteria), vaginal smears and intra-oral plaque samples were studied. Cytokine levels in amniotic fluid were studied in relation to other study variables. RESULTS: Periodontitis was diagnosed in 20% of normal and in 83% of preterm birth cases (p<0.01). Bacteria were never found in the amniotic fluids studied. Sub-gingival plaque samples including bacteria in the orange and red complexes were found in 18% of full-term 100% of preterm cases (p<0.001) and total colony-forming units (CFUs) were higher in preterm birth (p<0.01). Amniotic levels of interleukin (IL)-6 and prostaglandin-E2 (PGE2) were higher in preterm cases (p<0.001). Amniotic IL-6 (r=0.56, p<0.01) and PGE2 (r=0.50, p<0.01) cytokine levels were correlated with CFU from sub-gingival plaque samples (r2=0.44). The odds ratio of preterm delivery and having periodontitis was 20.0 (95% confidence interval (CI): 2.0-201.7, p<0.01). The odds of >60 CFU in sub-gingival plaque and preterm birth was 32.5:1 (95% CI: 3.0-335.1, p<01). CONCLUSIONS: Pregnant women with findings of elevated amniotic fluid levels of PGE2, IL-6 and IL-8 in the 15-20 weeks of pregnancy and with periodontitis are at high risk for premature birth. The implication of this is that periodontitis can induce a primary host response in the chorioamnion leading to preterm birth. |
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Authors:
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Orhun Dörtbudak; Rita Eberhardt; Martin Ulm; G Rutger Persson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of clinical periodontology Volume: 32 ISSN: 0303-6979 ISO Abbreviation: J. Clin. Periodontol. Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-01-11 Completed Date: 2005-03-31 Revised Date: 2009-11-03 |
Medline Journal Info:
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Nlm Unique ID: 0425123 Medline TA: J Clin Periodontol Country: Denmark |
Other Details:
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Languages: eng Pagination: 45-52 Citation Subset: D; IM |
Copyright Information:
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Copyright Blackwell Munksgaard, 2004. |
Affiliation:
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Department of Periodontology and Fixed Prosthodontics, University of Bern, Switzerland. orhun.doertbudak@meduniwien.ac.at |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Amniotic Fluid / chemistry, microbiology Colony Count, Microbial Cytokines / analysis Dental Plaque / microbiology Enzyme-Linked Immunosorbent Assay Female Humans Odds Ratio Periodontal Pocket / microbiology Periodontitis / complications* Pregnancy Pregnancy Complications, Infectious* / microbiology Premature Birth / etiology*, microbiology Statistics, Nonparametric Vagina / microbiology Vaginal Smears |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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