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Periodontitis in Patients With Coronary Artery Disease: An 8-year Follow-up.
MedLine Citation:
PMID:  23725030     Owner:  NLM     Status:  Publisher    
Aim: To study if preceding assessment of periodontal status in patients with established coronary artery disease (CAD) can predict future CAD endpoints (myocardial infarction, new revascularization procedure or CAD-related death) during 8-year follow-up, and if the changes in periodontal status over time differ in patients with CAD compared to healthy controls. Methods: In 2003, periodontal status was examined in 161 CAD patients who underwent percutaneous coronary intervention or coronary artery by-pass graft due to significant stenosis in the coronary arteries, and in 162 controls without CAD history. Eight years later, 126 CAD patients (mean age 68± 8.9, 102 men) and 121 controls (mean age 69± 9.0, 101 men) were periodontally re-examined. A standard classification of periodontal disease in three groups (mild, moderate and severe) was used. CAD endpoints during follow-up were obtained by review of medical records. Cause of death due to CAD was confirmed from the Swedish Cause of Death Register. Results: No significant differences were found among CAD patients with or without CAD related endpoints at 8 year follow-up and severity of periodontitis at baseline (P =0.7). CAD did not influence the incidence or severity of periodontitis over time. Significant differences were found at the final examination in periodontitis prevalence and severity (P =0.001), number of teeth (P =0.006), probing pocket depth 4-6 mm (P =0.016), bleeding on probing (P =0.001) and radiographic bone level (P =0.042) between CAD-patients and controls, all in favour of controls Conclusion: The study results did not show a significant association between CAD endpoints during 8 years and periodontal status at baseline. The progression of periodontitis was low in booth groups although the higher proportion of individuals with severe periodontitis among CAD patients compared to controls remained unchanged over the 8 year follow up. Further long-term prospective studies are needed to show whether periodontitis can be considered a risk or prognostic factor for CAD, in terms of endpoints including myocardial infarction, new revascularization procedure or CAD-related death.
Carin Starkhammar Johansson; Nils Ravald; Christos Pagonis; Arina Richter
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-5-31
Journal Detail:
Title:  Journal of periodontology     Volume:  -     ISSN:  1943-3670     ISO Abbreviation:  J. Periodontol.     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-6-3     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8000345     Medline TA:  J Periodontol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Div. of Cardiovascular Medicine, Dept. of Medical and Health Sciences, Linköping University, Centre for Oral Rehabilitation, County Council of Östergötland, Linköping, Sweden.
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