Document Detail


Periodontitis predicts elevated C-reactive protein levels in chronic kidney disease.
MedLine Citation:
PMID:  21940520     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Based on the existing evidence supporting a state of chronic inflammation in chronic kidney disease (CKD), we hypothesized that periodontal infection may affect the systemic inflammatory status of a nationally representative CKD population as measured by serum C-reactive protein (CRP). We examined this hypothesis using the National Health and Nutrition Examination Survey 1988-1994 (NHANES III) dataset including 2303 individuals. We followed the American Academy of Periodontology (AAP)/Centers for Disease Control and Prevention (CDC) case definition for periodontitis. We used a cutoff point of 30% sites with (PD) ≥ 5 mm and (CAL) ≥ 4 mm to define generalized periodontitis cases. We estimated glomerular filtration rate based on cystatin C levels using the relevant equation. Urinary albumin-to-creatinine ratio was calculated in milligrams per gram with a cutoff point of 30 mg/g. CKD was defined based on eGFR < 60 mL/min/1.73 m(2) and albuminuria ≥ 30 mg/g. Periodontitis was found in 427 (12.3%) individuals. Of individuals with periodontitis, 41.8% had serum CRP higher than 0.3 mg/dL compared with 27.1% of non-periodontitis and 53.1% of edentulous individuals (p = 0.001 for all comparisons). When the extent of periodontitis was used as one of the independent variables, the parsimonious model showed a strong independent association between extent of periodontitis and serum CRP levels (OR = 2.0, CI95% = 1.2-3.6).
Authors:
E Ioannidou; H Swede; A Dongari-Bagtzoglou
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-09-22
Journal Detail:
Title:  Journal of dental research     Volume:  90     ISSN:  1544-0591     ISO Abbreviation:  J. Dent. Res.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-11-15     Completed Date:  2012-01-10     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  0354343     Medline TA:  J Dent Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1411-5     Citation Subset:  D; IM    
Affiliation:
Division of Periodontology, Department of Oral Health and Diagnostic Sciences, University of Connecticut Health Center, Farmington, CT 06030, USA. Ioannidou@uchc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Albuminuria / diagnosis
C-Reactive Protein / analysis*
Chi-Square Distribution
Chronic Periodontitis / blood*,  complications
Female
Glomerular Filtration Rate
Humans
Kidney Failure, Chronic / blood*,  complications
Logistic Models
Male
Predictive Value of Tests
Young Adult
Grant Support
ID/Acronym/Agency:
K23 DE018689/DE/NIDCR NIH HHS; K23 DE018689-03/DE/NIDCR NIH HHS; K23DE018689/DE/NIDCR NIH HHS; M01RR06192/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
9007-41-4/C-Reactive Protein
Comments/Corrections
Comment In:
J Evid Based Dent Pract. 2012 Sep;12(3):171-3   [PMID:  22935291 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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