| Periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease. | |
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MedLine Citation:
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PMID: 22882677 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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AIM: To determine the relationship between periodontal pathogen load and anti-human heat shock protein 60 (hHSP60) antibodies in patients with established cardiovascular disease (CVD). MATERIALS AND METHODS: Participants were cardiovascular patients (n = 74) with a previous hospital admission for myocardial infarction. Concurrent periodontal pathogen load of Porphyromonas gingivalis, Fusobacterium nucleatum, Tannerella forsythia and Aggregatibacter actinomycetemcomitans was determined using quantitative real-time PCR. Serum antibodies to these pathogens, GroEL and hHSP60 were determined using an ELISA. RESULTS: There was a trend for increasing anti-hHSP60 antibody as the number of bacterial species increased. The strongest positive correlations were found between anti-hHSP60 levels and numbers of T. forsythia (r = 0.43; p < 0.001) and between anti-hHSP60 and anti-GroEL levels (r = 0.39; p = 0.001). Patients with extensive periodontal pocketing (≥4 mm) had higher numbers of P. gingivalis and T. forsythia (p < 0.05) and a higher subgingival pathogen load (p < 0.05) than patients with minimal pocketing (≤1 site ≥ 4 mm). They also had significantly elevated anti-hHSP60 levels (p < 0.05). Overall, the highest anti-hHSP60 levels were seen in patients with extensive periodontal pocketing and all four bacterial species. CONCLUSIONS: In cardiovascular patients, a greater burden of subgingival infection with increased levels of P. gingivalis and T. forsythia is associated with modestly higher anti-hHSP60 levels. |
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Authors:
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Shaneen J Leishman; Pauline J Ford; Hong Lien Do; Janet E Palmer; Nicholas C K Heng; Malcolm J West; Gregory J Seymour; Mary P Cullinan |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-7-11 |
Journal Detail:
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Title: Journal of clinical periodontology Volume: - ISSN: 1600-051X ISO Abbreviation: J. Clin. Periodontol. Publication Date: 2012 Jul |
Date Detail:
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Created Date: 2012-8-13 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0425123 Medline TA: J Clin Periodontol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 John Wiley & Sons A/S. |
Affiliation:
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School of Dentistry, The University of Queensland, Brisbane, Australia; School of Medicine, The University of Queensland, Brisbane, Australia. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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