| Periodontal disease is significantly higher in non-smoking treatment-naive rheumatoid arthritis patients: results from a case-control study. | |
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MedLine Citation:
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PMID: 22875903 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To find the strength of association between periodontal disease (PD) and rheumatoid arthritis (RA) in non-smoking, disease modifying antirheumatic drug (DMARD)-naive RA patients in a case-control design. METHODS: Patients of RA (DMARD-naive, non-smokers) satisfying the American college of Rheumatology 1987 criteria and healthy controls were included. PD was defined as present if the mean pocket depth (MPD) is ≥3 mm. Demographic data and disease specific variables were recorded for RA patients and healthy controls. Titres of immunoglobulin M-rheumatoid factor (IgM-RF) and anticitrullinated peptide antibodies (ACPAs) were measured using ELISA. RESULTS: Patients with RA (n=91) had a 4.28 (CI 2.35 to 7.38) higher odds of PD (64.8% vs 28%, p<0.001) compared with healthy controls (n=93). The MPD was 3.61±1.22 mm in cases and 2.46±0.74 mm in controls (p<0.001). IgM-RF titres (110.56±95.81 vs 66.53±70.29; p=0.02) and ACPA titres (753.05±1088.27 vs 145.15±613.16, p=0.001) were significantly higher in RA patients with PD than those without PD. The MPD positively correlated with titres of ACPAs in RA patients (r=0.24; p=0.02). CONCLUSIONS: PD is more frequent and severe in non-smoking DMARD-naive RA patients compared with healthy controls. PD in RA is associated with high titres of ACPAs. |
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Authors:
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Damodaram Potikuri; Kalyan Chakravarthy Dannana; Suresh Kanchinadam; Sumeet Agrawal; Anuradha Kancharla; Liza Rajasekhar; Shantakumari Pothuraju; Narsimulu Gumdal |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Annals of the rheumatic diseases Volume: 71 ISSN: 1468-2060 ISO Abbreviation: Ann. Rheum. Dis. Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-08-09 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372355 Medline TA: Ann Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 1541-4 Citation Subset: IM |
Affiliation:
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Correspondence to Dr G Narsimulu, Department of Rheumatology, Nizam's Institute of Medical Sciences, Hyderabad 500082, India; narsimuluhyderabad@gmail.com. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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