Document Detail

Periodontal disease as a risk factor for adverse pregnancy outcomes: a systematic review and meta-analysis of case-control studies.
MedLine Citation:
PMID:  21739194     Owner:  NLM     Status:  MEDLINE    
Periodontal disease is a highly prevalent group of illnesses of microbial etiology, whose consequence is a severe breakdown of tooth-supporting structures. A link between periodontal infection and several systemic conditions, among which adverse pregnancy outcomes, has been suggested in the recent years. The aim of this review based on case-control studies was to evaluate if periodontal disease could be considered as a risk factor for preterm birth, low birth-weight and preterm low birth-weight. An electronic search (via Pubmed) was performed for case-control studies investigating the relationship between periodontal disease and adverse pregnancy outcomes. From the initially retrieved 417 articles, 17 case-control studies, accounting for a total of 10,148 patients, were included in the review and in the meta-analysis. The estimated odds ratio was 1.78 (CI 95%: 1.58, 2.01) for preterm birth, 1.82 (CI 95%: 1.51, 1.20) for low birth-weight and 3.00 (CI 95%: 1.93, 4.68) for preterm low birth-weight. Despite the results of the analysis of pooled data suggested a link between periodontal diseases and adverse pregnancy outcomes, the presence of important confounders, whose effect could not be addressed, prevents a validation of the meta-analysis outcomes. Further more accurate investigations based on individual data analysis could give a better insight into the topic of the present review.
Stefano Corbella; Silvio Taschieri; Luca Francetti; Francesca De Siena; Massimo Del Fabbro
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Publication Detail:
Type:  Journal Article; Meta-Analysis; Review     Date:  2011-07-08
Journal Detail:
Title:  Odontology / the Society of the Nippon Dental University     Volume:  100     ISSN:  1618-1255     ISO Abbreviation:  Odontology     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-07-19     Completed Date:  2013-05-24     Revised Date:  2013-09-12    
Medline Journal Info:
Nlm Unique ID:  101134822     Medline TA:  Odontology     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  232-40     Citation Subset:  D; IM    
Department of Health Technologies, IRCCS Istituto Ortopedico Galeazzi, University of Milan, Milan, Italy.
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MeSH Terms
Case-Control Studies
Infant, Low Birth Weight
Infant, Newborn
Infant, Premature
Periodontal Diseases / complications
Pregnancy Complications, Infectious*
Pregnancy Outcome*
Premature Birth / etiology
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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