Document Detail

Periodontal disease and adverse pregnancy outcomes: a systematic review.
MedLine Citation:
PMID:  16411989     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Recent studies suggest that periodontal disease, as a source of subclinical and persistent infection, may induce systemic inflammatory responses that increase the risk of adverse pregnancy outcomes. OBJECTIVES: To examine the existing evidence on the relationship between periodontal disease and adverse pregnancy outcomes. SEARCH STRATEGY: Published studies identified via searches of the MEDLINE, EMBASE, CINAHL, and Current Contents full-text databases. SELECTION CRITERIA: We identified and selected observational studies (i.e. case-control, cross-sectional, and cohort) and nonrandomised controlled studies or randomised controlled trials that examined periodontal disease as a risk factor for adverse pregnancy outcomes. DATA COLLECTION AND ANALYSIS: Odds ratios (OR) or risk ratios (RR) were extracted or calculated from the studies' data. We calculated pooled effect size for two clinical controlled trials but not for the observational studies due to the heterogeneity in definitions for periodontal disease and adverse pregnancy outcomes across studies. MAIN RESULTS: Twenty-five studies (13 case-control, 9 cohort, and 3 controlled trials) were identified. The studies focused on preterm low birthweight, low birthweight, preterm birth, birthweight by gestational age, miscarriage or pregnancy loss, and pre-eclampsia. Of the chosen studies, 18 suggested an association between periodontal disease and increased risk of adverse pregnancy outcome (ORs ranging from 1.10 to 20.0) and 7 found no evidence of an association (ORs ranging from 0.78 to 2.54). Three clinical trial studies suggest that oral prophylaxis and periodontal treatment can lead to a 57% reduction in preterm low birthweight (pooled RR 0.43; 95% CI 0.24-0.78) and a 50% reduction in preterm births (RR 0.5; 95% CI 0.20-1.30). AUTHOR'S CONCLUSIONS: Periodontal disease may be associated with an increased risk of adverse pregnancy outcome. However, more methodologically rigorous studies are needed for confirmation.
X Xiong; P Buekens; W D Fraser; J Beck; S Offenbacher
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  BJOG : an international journal of obstetrics and gynaecology     Volume:  113     ISSN:  1470-0328     ISO Abbreviation:  BJOG     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-04-04     Revised Date:  2006-08-24    
Medline Journal Info:
Nlm Unique ID:  100935741     Medline TA:  BJOG     Country:  England    
Other Details:
Languages:  eng     Pagination:  135-43     Citation Subset:  AIM; IM    
Department of Epidemiology, School of Public Health and Tropical Medicine, Tulane University, New Orleans, Louisiana 70112, USA.
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MeSH Terms
Abortion, Spontaneous / etiology
Fetal Growth Retardation / etiology
Infant, Low Birth Weight
Infant, Newborn
Periodontal Diseases / complications*
Pre-Eclampsia / etiology
Pregnancy Complications / etiology*
Pregnancy Outcome
Premature Birth / etiology
Comment In:
BJOG. 2006 Jul;113(7):848; author reply 848-9   [PMID:  16753047 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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