Document Detail


Periodontal bacteria and hypertension: the oral infections and vascular disease epidemiology study (INVEST).
MedLine Citation:
PMID:  20453665     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Chronic infections, including periodontal infections, may predispose to cardiovascular disease. We investigated the relationship between periodontal microbiota and hypertension.
METHODS AND RESULTS: Six hundred and fifty-three dentate men and women with no history of stroke or myocardial infarction were enrolled in INVEST. We collected 4533 subgingival plaque samples (average of seven samples per participant). These were quantitatively assessed for 11 periodontal bacteria using DNA-DNA checkerboard hybridization. Cardiovascular risk factor measurements were obtained. Blood pressure and hypertension (SBP > or =140 mmHg, DBP > or =90 mmHg or taking antihypertensive medication, or self-reported history) were each regressed on the level of bacteria: considered causative of periodontal disease (etiologic bacterial burden); associated with periodontal disease (putative bacterial burden); and associated with periodontal health (health-associated bacterial burden). All analyses were adjusted for age, race/ethnicity, sex, education, BMI, smoking, diabetes, low-density lipoprotein and high-density lipoprotein cholesterol. Etiologic bacterial burden was positively associated with both blood pressure and prevalent hypertension. Comparing the highest and lowest tertiles of etiologic bacterial burden, SBP was 9 mmHg higher, DBP was 5 mmHg higher (P for linear trend was less than 0.001 in each case), and the odds ratio for prevalent hypertension was 3.05 (95% confidence interval 1.60-5.82) after multivariable adjustment.
CONCLUSION: Our data provide evidence of a direct relationship between the levels of subgingival periodontal bacteria and both SBP and DBP as well as hypertension prevalence.
Authors:
Moïse Desvarieux; Ryan T Demmer; David R Jacobs; Tatjana Rundek; Bernadette Boden-Albala; Ralph L Sacco; Panos N Papapanou
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  28     ISSN:  1473-5598     ISO Abbreviation:  J. Hypertens.     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-24     Completed Date:  2010-12-17     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1413-21     Citation Subset:  IM    
Affiliation:
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA. md108@columbia.edu
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MeSH Terms
Descriptor/Qualifier:
Aged
Antihypertensive Agents / therapeutic use
Blood Pressure
Cardiovascular Diseases / complications,  drug therapy,  etiology
Cohort Studies
Dental Plaque / complications,  drug therapy,  microbiology
Diabetes Mellitus / drug therapy
Female
Humans
Hypertension / blood,  complications*,  drug therapy
Male
Periodontal Diseases / complications*,  drug therapy,  microbiology
Prevalence
Prospective Studies
Risk
Grant Support
ID/Acronym/Agency:
1UL1RR024156/RR/NCRR NIH HHS; K99 DE-018739/DE/NIDCR NIH HHS; NS-29993/NS/NINDS NIH HHS; R00 DE018739/DE/NIDCR NIH HHS; R01 DE-13094/DE/NIDCR NIH HHS; R01 DE013094/DE/NIDCR NIH HHS; R01 NS-047655/NS/NINDS NIH HHS; R01 NS029993/NS/NINDS NIH HHS; R01 NS047655/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Antihypertensive Agents
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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