| Periodontal Disease Decreases Insulin Sensitivity and Insulin Signaling. | |
| | |
MedLine Citation:
|
PMID: 22087804 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: The purpose of this study was to investigate whether local inflammatory events, such as periodontal disease, are able to increase TNF-? plasmatic concentration, and decrease insulin sensitivity and insulin signaling in non-diabetic rats. Methods: Forty-eight male Wistar rats (at two months old) were divided into two groups, with either ligature-induced periodontal disease (PD) or control conditions (CN). Experiments were carried out in both groups twenty-eight days following ligature placement. Plasmatic concentration of glycemia and TNF (n=10) were analyzed by the glucose oxidase and ELISA method, respectively. Insulin sensitivity (n=7) were measured using the insulin tolerance test (ITT). Insulin signal transduction (n=7) was measured by pp185 tyrosine phosphorylation status in insulin-sensitive tissues using the western blotting method. Results: The PD group showed decreased insulin sensitivity (p<0.05), although no glycemic alterations were noted (p>0.05). TNF plasmatic concentration was higher in PD rats compared to control. In addition, a decrease in the pp185 tyrosine phosphorylation status was observed following insulin stimulus in both white adipose and skeletal muscle tissues of the PD group compared to the control group. Conclusions: Periodontal disease is able to cause alterations to both insulin signaling and insulin sensitivity, probably due to the elevation of TNF-? plasmatic concentration. Thus, the present results emphasize the importance of the prevention of local inflammatory diseases, such as periodontitis, to prevent diabetes mellitus. |
| | |
Authors:
|
Natalia H Colombo; Daisy J Shirakashi; Fernando Y Chiba; Maria Sara de Lima Coutinho; Edilson Ervolino; Cl A Adas Saliba Garbin; Ubiratan Fabres Machado; Doris H Sumida |
Related Documents
:
|
15513964 - Meal-related increases in vascular reactivity are impaired in older and diabetic adults... 15607574 - Low-insulin-response diets may decrease plasma c-reactive protein by influencing adipoc... 3883804 - Role of palatability on meal-induced thermogenesis in human subjects. 17046544 - Postprandial thrombin activatable fibrinolysis inhibitor and markers of endothelial dys... 10977014 - Secular trends in birth weight, bmi, and diabetes in the offspring of diabetic mothers. 6406544 - Lipoxygenase pathway in islet endocrine cells. oxidative metabolism of arachidonic acid... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-16 |
Journal Detail:
|
Title: Journal of periodontology Volume: - ISSN: 1943-3670 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-17 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8000345 Medline TA: J Periodontol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Basic Sciences, Dental School of Ara?atuba, S?o Paulo State University -UNESP, Brazil. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Double-Blind Randomized Clinical Trial Evaluating the Effect of a Triclosan/Copolymer Dentifrice on ...
Next Document: Clinical and Microbiological Effects of Commercially Available Dentrifice Containing Aloe vera: A Ra...